Growth hormone deficiency in three siblings homozygous for a rare GH1 haplotype [PDF]
Frontiers in EndocrinologyIntroductionGrowth Hormone (GH), secreted by the anterior pituitary gland, is a key regulator of postnatal growth. Mutations in the GH1 gene can lead to isolated GH deficiency (IGHD), a rare disorder characterized by growth failure and severe short ...
Manuel C. Lemos +2 more
exaly +4 more sources
Analysis of Genetic Factors in a Family With Short Stature. [PDF]
Mol Genet Genomic MedWe identified pathogenic variants of two different genes, COL1A2 and GH1, in a family with short stature through trio‐WES, thereby providing a clear genetic diagnosis for this family. ABSTRACT Background To elucidate the genetic underpinnings of short stature in a familial cohort of five individuals.
Zhang S, Zuo T, Deng Y, Zhao D, Liao L.
europepmc +2 more sources
Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes. [PDF]
FEBS JCold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Digiovanni S +5 more
europepmc +2 more sources
Evolutionary Dynamics of Glycoside Hydrolase Family 1 Provide Insights into Insect–Plant Interactions in Lepidoptera [PDF]
InsectsGlycoside hydrolase family 1 (GH1) enzymes are essential for plant cell wall digestion and the detoxification of plant metabolites in insects, yet their evolutionary history in Lepidoptera remains unresolved.
Yanping Yuan +7 more
doaj +2 more sources
Adaptive Diversification of the Mstnb Locus Drives Genomic Architecture of Growth in Thai Clariid Catfish [PDF]
Evol ApplABSTRACT The production of clariid catfish in Thai aquaculture depends on culture of the native species (Clarias macrocephalus and C. batrachus) and introduced African catfish (C. gariepinus). Particularly, hybridization with C. gariepinus has improved productivity but raised significant conservation concerns.
Nguyen T +19 more
europepmc +2 more sources
Mechanism of imidazole inhibition of a GH1 β-glucosidase
FEBS Open Bio, 2023 Imidazole is largely employed in recombinant protein purification, including GH1 β‐glucosidases, but its effect on the enzyme activity is rarely taken into consideration.
Sandro R. Marana +2 more
exaly +2 more sources
Boosting Recombinant Bovine Chymosin in Komagataella phaffii via Fusion Protein and Constitutive Promoter Expression [PDF]
FoodsBovine chymosin is key for cheese production, yet its traditional sourcing is unsustainable. While microbial and plant-based alternatives exist, they often cause non-specific proteolysis, leading to bitter flavors in cheese.
Xinrun Ren +8 more
doaj +2 more sources
Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-scores [PDF]
Frontiers in PediatricsBackgroundSeveral maternal hormones regulate fetal growth, but concentrations of these hormones in pregnancy among women living with HIV and associations between hormone levels and infant anthropometrics is limited.MethodsPregnant women with HIV ...
Kathleen M. Powis +17 more
doaj +2 more sources
Insects, 2022 Insects closely interact with plants with multiple genes involved in their interactions. β-glucosidase, constituted mainly by glycoside hydrolase family 1 (GH1), is a crucial enzyme in insects to digest plant cell walls and defend against natural enemies
Shulin He +3 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2022 Objective: To determine the inhibition mechanisms of secretome protein extracted from Paenibacillus polymyxa Kp10 (Kp10) and Lactococcus lactis Gh1 (Gh1) against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus ...
Nurul Hana Zainal Baharin +11 more
doaj +1 more source