Results 1 to 10 of about 13,772 (173)

Growth hormone deficiency in three siblings homozygous for a rare GH1 haplotype [PDF]

Frontiers in Endocrinology
IntroductionGrowth Hormone (GH), secreted by the anterior pituitary gland, is a key regulator of postnatal growth. Mutations in the GH1 gene can lead to isolated GH deficiency (IGHD), a rare disorder characterized by growth failure and severe short ...
Manuel C Lemos, Abdalla Ebtesam
exaly   +7 more sources

Mechanism of imidazole inhibition of a GH1 β‐glucosidase

FEBS Open Bio, 2023
Imidazole is largely employed in recombinant protein purification, including GH1 β‐glucosidases, but its effect on the enzyme activity is rarely taken into consideration.
Rafael S. Chagas, Felipe A. M. Otsuka, Mario A. R. Pineda, Roberto K. Salinas, Sandro R. Marana   +4 more
doaj   +3 more sources

Evolutionary Dynamics of Glycoside Hydrolase Family 1 Provide Insights into Insect–Plant Interactions in Lepidoptera [PDF]

Insects
Glycoside hydrolase family 1 (GH1) enzymes are essential for plant cell wall digestion and the detoxification of plant metabolites in insects, yet their evolutionary history in Lepidoptera remains unresolved.
Yanping Yuan, Xidan Zhang, Jinyu Wu, Jun Li, Zhengbo He, Wenbo Fu, Amrita Chakraborty, Shulin He   +7 more
doaj   +2 more sources

Boosting Recombinant Bovine Chymosin in Komagataella phaffii via Fusion Protein and Constitutive Promoter Expression [PDF]

Foods
Bovine chymosin is key for cheese production, yet its traditional sourcing is unsustainable. While microbial and plant-based alternatives exist, they often cause non-specific proteolysis, leading to bitter flavors in cheese.
Xinrun Ren, Xiaoyan Ning, Bo Liu, Xinxin Xu, Lina Men, Angie Deng, Yuhong Zhang, Zhiwei Zhang, Wei Zhang   +8 more
doaj   +2 more sources

Genome-wide identification and analysis of GH1-containing H1 histones among poplar species [PDF]

BMC Genomics
Histone H1s are basic nuclear proteins, which played key role in the binding of DNA and nucleosome, eventually the stability of eukaryotic chromatin. In most species, H1s possess an evolutionarily conserved nucleosome-DNA binding globular domain (GH1 ...
Ping Li, Jing Wang, Qimin Zhang, Anmin Yu, Rui Sun, Aizhong Liu   +5 more
doaj   +2 more sources

Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars [PDF]

Bioorganic Chemistry, 2019
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives and tri- or hexavalent alkynyl scaffolds is reported. The new multimeric compounds, together with the monomeric reference, were evaluated as inhibitors against two homologous GH1 β-glucosidases (BglA and BglB from Paenibacillus ...
Macarena Martínez-Bailén, Julio Polaina, Antonio Jose Moreno Vargas   +2 more
exaly   +8 more sources

Structural variation in the <i>GH1</i> promoter regulates the hull color of rice. [PDF]

Mol Breed
Rice hull color (HC) is crucial for improving the mechanization efficiency of hybrid rice seed production. However, the genetic resources for hull color currently available for practical production are limited, highlighting an urgent need to explore natural variations that can be utilized in breeding.
Du C, Wang H, Zhong G, Yan X, Di K, Li L, Zhang S, Yang N, Wang Y, Chen W, Yuan H, Tu B, Xiong J, Zhong Z, Wang Y, Li S, Qin P, Ma B.   +17 more
europepmc   +3 more sources

Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-scores [PDF]

Frontiers in Pediatrics
BackgroundSeveral maternal hormones regulate fetal growth, but concentrations of these hormones in pregnancy among women living with HIV and associations between hormone levels and infant anthropometrics is limited.MethodsPregnant women with HIV ...
Kathleen M. Powis, Kathleen M. Powis, Kathleen M. Powis, Jennifer Jao, Jennifer Jao, Jennifer Jao, Justine Legbedze, Caroline Dunk, Keolebogile N. Mmasa, Samuel W. Kgole, Gosego Masasa, Terence Mohammed, Joseph Makhema, Sikhulile Moyo, Mitchell E. Geffner, Elaine J. Abrams, Lena Serghides, Lena Serghides   +17 more
doaj   +2 more sources

Impact of Changes in Buffer Ionic Concentration and Mutations on a GH1 β‑Glucosidase Homodimer. [PDF]

ACS Omega
Abstract Oligomerization is a key feature of protein function, with approximately 30% of proteins exhibiting this trait. The homodimeric form of proteins, such as the GH1 β-Glucosidase from Spodoptera frugiperda (Sfβgly), plays a significant role in enzyme activity.
Chagas RS, Marana SR.
europepmc   +3 more sources

Tris inhibits a GH1 β-glucosidase by a linear mixed inhibition mechanism.

PLoS ONE
Here we demonstrate that Tris (2-amino-2-(hydroxymethyl)-1,3-propanediol), largely used as a buffering agent, is a linear mixed inhibitor (Ki =  12 ±  2 mM and α =  3 ±  1) of the GH1 β-glucosidase from the insect Spodoptera frugiperda (Sfβgly).
Rafael S Chagas, Sandro R Marana
doaj   +3 more sources