GH-resistant (Laron) mice: gene therapy with a liver-specific GH receptor causes unbalanced upregulation of female-biased and growth-related genes [PDF]
Frontiers in EndocrinologyGrowth hormone (GH) receptor (GHR) mutations give rise to GH-resistance (Laron syndrome). We previously treated GH-resistant Ghr-/- mice (Laron mice) with adeno-associated virus (AAV) delivering mouse (m)Ghr controlled by a constitutively active liver ...
Joshua K. Tay +10 more
doaj +2 more sources
Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction. [PDF]
Aging CellHepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Yang K +7 more
europepmc +2 more sources
Biomolecules, 2023 Laron syndrome (LS) is a rare genetic disorder characterized by low levels of insulin-like growth factor 1 (IGF1) and high levels of growth hormone (GH) due to mutations in the growth hormone receptor gene (GHR). A GHR-knockout (GHR-KO) pig was developed
Eckhard Wolf +2 more
exaly +3 more sources
How do global health research actors conceptualise inclusion in response to decolonisation calls? A scoping review [PDF]
BMJ Global HealthBackground There are growing calls to decolonise global health research (GHR). One way actors respond to these calls is through placing greater emphasis on inclusion.
Cornelius Ewuoso, Kenny Chiwarawara
doaj +2 more sources
Fasting blood glucose to high-density lipoprotein cholesterol ratio and MASLD risk: non-linear association and BMI mediation in non-diabetic adults [PDF]
Frontiers in NutritionBackgroundThe fasting blood glucose (FBG) to high-density lipoprotein cholesterol (HDL-C) ratio (GHR) integrates glucose and lipid metabolism, but its association with metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear.
Yanyan Xuan +4 more
doaj +2 more sources
Expression of a hindlimb-determining factor Pitx1 in the forelimb of the lizard Pogona vitticeps during morphogenesis [PDF]
Open Biology, 2016 With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology.
Jane Melville +5 more
doaj +1 more source
Frontiers in Endocrinology, 2021 PurposeLaron syndrome (LS) is a severe growth disorder caused by GHR gene mutation or post-receptor pathways defect. The clinical features of these patients collected in our present study were summarized, GHR gene variants were investigated and further ...
Ran Li +10 more
doaj +1 more source
ARCGHR Neurons Regulate Muscle Glucose Uptake
Cells, 2021 The growth hormone receptor (GHR) is expressed in brain regions that are known to participate in the regulation of energy homeostasis and glucose metabolism.
Juliana Bezerra Medeiros de Lima +10 more
doaj +1 more source
Significant down-regulation of growth hormone receptor expression revealed as a new unfavorable prognos- tic factor in hepatitis C virus-related hepatocellular carcinoma [PDF]
Clinical and Molecular Hepatology, 2021 Background/Aims Growth hormone (GH) is the main regulator of somatic growth, metabolism, and gender dimorphism in the liver. GH receptor (GHR) signaling in cancer is derived from a large body of evidence, although the GHR signaling pathway involved in ...
Ching-Chih Lin +9 more
doaj +1 more source
BMC Psychiatry, 2023 Background Schizophrenia (SZ) arises from a complex interplay involving genetic and molecular factors. Early intervention of SZ hinges upon understanding its vulnerability and resiliency factors in study of SZ and genetic high risk for SZ (GHR).
Jia Duan +10 more
doaj +1 more source