Results 11 to 20 of about 22,382 (200)
GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients [PDF]
Endocrine Connections, 2020 Objectives: The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity.
Sumana Chatterjee +8 more
doaj +6 more sources
Hypothalamic GHR—SIRT1 Axis in Fasting [PDF]
Cells, 2021 Many aspects of physiological functions are controlled by the hypothalamus, a brain region that connects the neuroendocrine system to whole-body metabolism. Growth hormone (GH) and the GH receptor (GHR) are expressed in hypothalamic regions known to participate in the regulation of feeding and whole-body energy homeostasis.
Juliana Bezerra Medeiros de Lima +5 more
openaire +4 more sources
Cell Communication and Signaling, 2023 Background Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in response to somatic growth.
Bowen Hu +9 more
doaj +2 more sources
, 2010 The GHR −/− mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR−/− mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues.
Gosney, Elahu S., Kopchick, John J.
openaire +3 more sources
Poultry ScienceN6-methyl-adenosine (m6A) methylation has recently been shown to play a critical role in muscle development. We recently revealed that local GHR knockdown impairs mitochondrial function by inhibiting mitochondrial biogenesis, thereby repressing myoblast ...
Changbin Zhao +6 more
doaj +2 more sources
GHR/HindIII Locus Polymorphisms in Intron-2 GHR Gene of Papua Local Chicken [PDF]
Jurnal Sain Peternakan Indonesia, 2021 This study aimed to detect single nucleotide polymorphisms (SNPs) in intron-2 on growth hormone receptor (GHR) gene in Papua local chickens using the PCR-RFLP method to study its relationship with growth characteristics. Data on the bodyweight of 49 chickens aged 1, 2, 3, and 4 months (22 males, 27 females) and DNA samples were used for this study. The
M. A. Mu'in, A. G. Murwanto
openaire +4 more sources
PRE-GHR Series Map — Canonical Reference for the PRE-GHR Publication Series
Canonical reference map for the PRE-GHR publication series: numbering map, layer architecture, versioning convention, citation format, related records, revision history. v25 (2026-08-12): adds PRE-GHR XLI (The Sandbox Has No Walls — Empirical Trace #5, concept DOI 10.5281/zenodo.21906112, v1 version DOI 21906113).
+32 more sources
Growth Hormone Receptor Regulation in Cancer and Chronic Diseases [PDF]
Frontiers in Endocrinology, 2020 The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control, immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC pathways. Dysregulation of GHR signaling is associated with various diseases
Ger J. Strous +9 more
doaj +3 more sources
GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers [PDF]
Molecular Endocrinology, 2016 GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane cytokine receptors. Each prehomodimerizes and ligand binding activates Janus Kinase 2 (JAK2)-signal transducer and activator of transcription (STAT) signaling pathways by inducing conformational changes within receptor homodimers.
Ying, Liu +8 more
openaire +2 more sources
Czech Journal of Animal Science, 2018 The association between several gene polymorphisms, the estimated breeding values for milk performance traits, and glucose metabolism measured by the glucose tolerance test (GTT) in German Holstein sires were evaluated.
Jindřich Čítek +5 more
doaj +1 more source