Results 41 to 50 of about 38,787 (232)
Recent Advances in Potential Clinical Application of Ghrelin in Obesity
Journal of Obesity, 2012 Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelin O-acyltransferase (GOAT).
Christine Delporte
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Frontiers in Endocrinology, 2019 Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with increased risk of cardiovascular disease and metabolic alterations. The mechanisms underlying these alterations remain unclear.
Mildren Porchas-Quijada +9 more
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Advanced Science, EarlyView.Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou +15 more
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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Periodontology 2000, EarlyView., 2023 Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti +2 more
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Acyl modifications in bovine, porcine, and equine ghrelins
Frontiers in EndocrinologyGhrelin is a peptide hormone with various important physiological functions. The unique feature of ghrelin is its serine 3 acyl-modification, which is essential for ghrelin activity.
Takanori Ida +17 more
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A review on ghrelin and fish reproduction
Reproduction and Breeding, 2021 Ghrelin is a multifunctional peptide hormone which dominantly secreted in stomach and intestine. Ghrelin involves in growth control, food intake, energy balance, and reproductive process.
Huan Zhong, Yi Hu, Fan Yu
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Nutrition Journal, 2009 Background For cachectic patients with chronic respiratory disease (CRD), conventional enteral nutrition formula is an optional treatment to maintain energy balance. The molecular mechanisms by which enteral nutrition formula controls appetite and weight
Nakazato Masamitsu +2 more
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Advanced Science, EarlyView.Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim +9 more
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Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling
Advanced Science, EarlyView.The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen +13 more
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Molecular and Cellular Endocrinology, 2011 Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular and immune systems. Ghrelin and its
Rachael Z. Murray +8 more
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