Results 111 to 120 of about 1,268,458 (245)

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Ghrelin in the regulation of feeding and energy balance [PDF]

, 2007
Ghrelin, the first identified endogenous ligand for the growth hormone secretagogue receptor 1A, is a 28 amino acid peptide produced mainly by the stomach. Pharmacological studies indicate a role for ghrelin in the regulation of growth hormone secretion
Chen, Duan, Lindqvist, Andreas, Dickson, Suzanne L, Håkanson, Rolf,, Egecioglu, Emil, Syversen, Unni, Dornonville de la Cour, Charlotta, Dickson, Suzanne L.,, Egecioglu, Emil,, Tung, Loraine Y C, Lindqvist, Andreas,, de la Cour, Charlotta, Pinnock, Scarlett B, de la Cour, Charlotta,, Håkanson, Rolf, Egecioglu, Emil 1977-, Lund University., Stenstrom, Bjorn   +17 more
core   +1 more source

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats

American Journal of Physiology-Endocrinology and Metabolism, 2008
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), is the only circulating agent to powerfully promote a positive energy balance. Such action is mediated predominantly by central nervous system pathways controlling food intake, energy expenditure, and nutrient partitioning.
Sabine, Strassburg, Stefan D, Anker, Tamara R, Castaneda, Lukas, Burget, Diego, Perez-Tilve, Paul T, Pfluger, Ruben, Nogueiras, Heather, Halem, Jesse Z, Dong, Michael D, Culler, Rakesh, Datta, Matthias H, Tschöp   +11 more
openaire   +3 more sources

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Ghrelin receptor in GtoPdb v.2025.3 [PDF]

The ghrelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Ghrelin receptor [19]) is activated by a 28 amino-acid peptide originally isolated from rat stomach, where it is cleaved from a 117 amino-acid precursor (GHRL, Q9UBU3). A
Holst, Birgitte, Maguire, Janet J., Davenport, Anthony P., Kleinz, Matthias, Sivertsen, Bjørn B., Romeral Buzón, Alejandro   +5 more
core   +1 more source

Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo [PDF]

, 2017
Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis. This study sought to analyze the expression of the functional receptor for ghrelin (GHS-R1a) in periodontal cells and tissues under ...
Götz, Werner, Svenja Memmert, Zhou, Xiaoyan, Nanayakkara, Shanika, Xiaoyan Zhou, Joni Augusto Cirelli, Cirelli, Joni Augusto [UNESP], Marjan Nokhbehsaim, Nokhbehsaim, Marjan, Damanaki, Anna, Deschner, James, Nogueira, Andressa Vilas Boas [UNESP], Werner Götz, Andreas Jäger, Memmert, Svenja, Jäger, Andreas, James Deschner, Andressa Vilas Boas Nogueira, Sigrun Eick, Anna Damanaki, Nogueira, Andressa Vilas Boas, Shanika Nanayakkara, Eick, Sigrun, Cirelli, Joni Augusto   +23 more
core   +2 more sources

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Journal of Diabetes Research, 2017
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases.
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira   +2 more
doaj   +1 more source

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source

Effects of Feeding Pattern on Plasma Ghrelin Concentrations in Pigs

, 2005
The independent role of ghrelin regulation continues to be controversial. Ghrelin, a 28 amino acid peptide identified as the endogenous ligand for growth hormone (GH) secretoagogue receptor, is found in the gastrointestinal tract, predominantly the ...
Brown, Caroline Elizabeth
core  

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

The Journal of Physiology, EarlyView.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source