Results 91 to 100 of about 20,015 (204)

The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective

Journal of Diabetes Research, 2017
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions are associated with increased risk for the development of other comorbidities and obesity-related diseases.
Jéssica Aparecida da Silva Pereira, Felipe Corrêa da Silva, Pedro Manoel Mendes de Moraes-Vieira   +2 more
doaj   +1 more source

Tuning Membrane Binding and Lipid Phase Preference of DNA Nanostructures via Synergistic Multi‐Lipidation

ChemSystemsChem, Volume 8, Issue 5, September 2026.
DNA origami nanostructures functionalized with lipophilic anchors of distinct hydrophobicity reveal synergistic effects on membrane binding and phase‐specific localization. Weak anchors, although insufficient for binding alone, enhance membrane association and govern selective phase partitioning when combined with strong anchors, establishing multi ...
Subhasini Singh, Henri G. Franquelim
wiley   +1 more source

Ghrelin–LEAP2 interactions along the stomach–liver axis

Endocrine Journal
Ghrelin produced in the stomach promotes food intake and GH secretion, and acts as an anabolic peptide during starvation. Ghrelin binds to the growth hormone secretagogue receptor, a G protein-coupled receptor (GPCR), whose high-resolution complex ...
Katsuya Sakai, Yuki Nakazato, Yuki Shiimura, Weidong Zhang, Masamitsu Nakazato   +4 more
doaj   +1 more source

Ghrelin receptor signaling in health and disease: a biased view. [PDF]

Trends Endocrinol Metab, 2023
Gross JD, Zhou Y, Barak LS, Caron MG.
europepmc   +1 more source

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice. [PDF]

Genes (Basel), 2023
Ye X, Liu Z, Han HW, Noh JY, Shen Z, Kim DM, Wang H, Guo H, Ballard J, Golovko A, Morpurgo B, Sun Y.   +11 more
europepmc   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice. [PDF]

Neuropharmacology, 2023
Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L.   +8 more
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Ghrelin receptor antagonist JMV2959 blunts cocaine and oxycodone drug-seeking, but not self-administration, in male rats. [PDF]

Front Pharmacol, 2023
Merritt CR, Garcia EJ, Brehm VD, Fox RG, Moeller FG, Anastasio NC, Cunningham KA.   +6 more
europepmc   +1 more source