Results 81 to 90 of about 1,268,458 (245)

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Immunohistochemical evidence for an endocrine/paracrine role for ghrelin in the reproductive tissues of sheep

Reproductive Biology and Endocrinology, 2005
Background The gut hormone, ghrelin, is involved in the neuroendocrine and metabolic responses to hunger. In monogastric species, circulating ghrelin levels show clear meal-related and body weight-related changes. The pattern of secretion and its role in
Brown Yvonne A, Harrison Joanne L, Miller David W, Doyle Una, Lindsay Alanna, Adam Clare L, Lea Richard G   +6 more
doaj   +1 more source

Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice. [PDF]

PLoS ONE, 2014
We explored the renal protective effects by a gut peptide, Ghrelin. Daily peritoneal injection with Ghrelin ameliorated renal damages in continuously angiotensin II (AngII)-infused C57BL/6 mice as assessed by urinary excretion of protein and renal ...
Keiko Fujimura, Shu Wakino, Hitoshi Minakuchi, Kazuhiro Hasegawa, Koji Hosoya, Motoaki Komatsu, Yuka Kaneko, Keisuke Shinozuka, Naoki Washida, Takeshi Kanda, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Itoh   +12 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal Outcomes

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective An increasing number of women of childbearing age worldwide are using glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and are advised to use effective contraception during treatment. Nevertheless, maternity services are encountering increasing numbers of women exposed to GLP‐1 RAs shortly before conception or during pregnancy ...
Katherine G. Y. Lau, Anisha Chopra, Edward Mullins, Rochan Agha‐Jaffar, Tricia Tan, Lynne Sykes, Christina K. H. Yu   +6 more
wiley   +1 more source

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models

Frontiers in Neuroscience, 2013
Ghrelin is an octanoylated peptide hormone, produced by endocrine cells of the stomach, which acts in the brain to increase food intake and body weight.
Aki eUchida, Jeffrey M. Zigman, Mario ePerello   +2 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Immunolocalization of Ghrelin and Its Functional Receptor, the Type 1a Growth Hormone Secretagogue Receptor, in the Cyclic Human Ovary

, 2003
Ghrelin is a novel 28-amino acid peptide identified as the endogenous ligand for the GH secretagogue receptor (GHS-R). Besides its hallmark central neuroendocrine effects in the control of GH secretion and food intake, an unexpected reproductive facet of
Chopin, Lisa K., Herington, Adrian C., L. K. Chopin, Casanueva, Felipe F., Dieguez, Carlos, C. Diéguez, Barreiro, M. Luz, F. Gaytan, Tena-Sempere, Manuel, L. Pinilla, Aguilar, Enrique, Gaytan, Felice, Morales, Concepcion, A. C. Herington, Pinilla, Leonor, M. Tena-Sempere, F. F. Casanueva, E. Aguilar, M. L. Barreiro, C. Morales   +19 more
core   +1 more source

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin [PDF]

Scientific Reports, 2019
AbstractThe peptide hormone acyl-ghrelin and its receptor, GHSR1a, represent intriguing therapeutic targets due to their actions in metabolic homeostasis and reward activity. However, this pleotropic activity makes it difficult to intervene in this system without inducing unwanted effects. Thus, it is desirable to identify passive and active regulatory
Wenthur, Cody J., Gautam, Ritika, Zhou, Bin, Vendruscolo, Leandro F., Leggio, Lorenzo, Janda, Kim D.   +5 more
openaire   +2 more sources

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

Journal of Experimental Pharmacology, 2020
Ehsan N Mohammadi,1 Tijs Louwies,1 Claudio Pietra,2 S Robert Northrup,3 Beverley Greenwood-Van Meerveld1 1Oklahoma Center for Neuroscience, Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA; 2Helsinn ...
N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B   +4 more
doaj