Results 151 to 160 of about 1,268,458 (245)
Energy homeostasis : crosstalk between adipose tissue and the human hypothalamus [PDF]
There is a worldwide epidemic of obesity. Weight rise is a consequence of continuous positive energy balance which leads to accumulation of body fat. Recent insights into adipose tissue (AT) biology have led to the conclusion that the adipocyte is not
Kos, Katarina
core
Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging. [PDF]
J Alzheimers Dis, 2023 Tian J +6 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.This study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Lixing Zhou +9 more
wiley +1 more source
Allosteric modulation of ghrelin receptor signaling by lipids. [PDF]
Nat Commun, 2021 Damian M +11 more
europepmc +1 more source
Addiction, Volume 121, Issue 10, Page 2682-2690, October 2026.Abstract Background and aims Increased risk of alcohol dependence is recognised following bariatric surgery. Modified gastrointestinal anatomy and neurohormonal profiles lead to altered alcohol metabolism, peak blood alcohol concentrations and enhanced reward circuits and cravings.
Thomas J. Williams +4 more
wiley +1 more source
The emerging role of heterodimerisation and interacting proteins in ghrelin receptor function. [PDF]
J Endocrinol, 2021 Price ML, Ley CD, Gorvin CM.
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8769-8776, October 2026.ABSTRACT Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have transformed the pharmacological management of obesity, producing substantial and sustained weight loss during active treatment. However, discontinuation of therapy is frequently followed by significant weight regain, raising important questions regarding the durability of treatment ...
M. A. Damhof +2 more
wiley +1 more source
Metabolic and serotonergic modulation of hypothalamic arcuate nucleus neurones in vitro [PDF]
1. The effects of glucose on the electrophysiological properties of rat hypothalamic arcuate nucleus (ARC) neurones were investigated. Neurones were recorded in 10 mM (hyperglycaemic) and 2 mM (euglycaemic) glucose-containing aCSF.
Saker, Louise
core
Intracerebroventricular injection of ghrelin receptor antagonist alleviated NAFLD via improving hypothalamic insulin resistance. [PDF]
Iran J Basic Med Sci, 2022 Gong Y +6 more
europepmc +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Abstract Early‐life exposure to metabolic hormones may influence the development of taste acceptance and subsequent intake of hyperpalatable foods (HPF) in infants, but evidence integrating hormonal, behavioral, and dietary data in humans is limited.
Ana Luz Kruger +12 more
wiley +1 more source