Results 151 to 160 of about 20,015 (204)
Ghrelin receptor in agouti-related peptide neurones regulates metabolic adaptation to calorie restriction. [PDF]
J Neuroendocrinol, 2019 Wu CS +8 more
europepmc +1 more source
Ghrelin Receptor Signaling Is Not Required for Glucocorticoid-Induced Obesity in Male Mice.
Endocrinology, 2020 Hay RE +7 more
europepmc +1 more source
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice [PDF]
Peptides, 2011 Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection.
Yuxiang Sun, Roy G Smith
exaly +3 more sources
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor [PDF]
Cell Metabolism, 2018 Ghrelin, an appetite-stimulatory hormone secreted by the stomach, was discovered as a ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin stimulates growth hormone (GH) secretion, a function that evolved to protect against starvation-induced hypoglycemia.
Lutz Jermutus +2 more
exaly +3 more sources
Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
Molecular and Cellular Endocrinology, 2013 Ghrelin is a potent orexigenic brain-gut peptide with lipogenic and diabetogenic effects, possibly mediated by growth hormone secretagogue receptor (GHS-R1a). Cannabinoids also have orexigenic and lipogenic effects. AMPK is a regulator of energy homeostasis and we have previously shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity ...
Diego Pérez-Tilve +2 more
exaly +3 more sources
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Ghrelin Receptors and Epilepsy
2014Epilepsy is a neurological disorder that affects more than 50 million people worldwide. One-third of all epilepsy patients do not respond to the antiepileptic medications that are currently available. As such, there is a great need for new, more effective drugs for the treatment of epilepsy.
Portelli, Jeanelle +3 more
openaire +2 more sources
Ghrelin and ghrelin receptor inhibitors: agents in the treatment of obesity
Expert Opinion on Therapeutic Targets, 2008Current medical treatment of obesity is highly ineffective. Soon after its discovery as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R), ghrelin was shown to stimulate food intake (including in humans) and promote body weight gain and adipogenesis.This review discusses the role of the ghrelin/GHS-R pathway in energy ...
João-Bruno, Soares +2 more
openaire +2 more sources
Ghrelin Receptor Modulators and Their Therapeutic Potential
Future Medicinal Chemistry, 2009Ghrelin is a peptide produced predominantly in the stomach and intestines, and is a natural growth hormone (GH) secretagogue-receptor ligand. It is able to stimulate GH release, but it also exhibits an important role in conditions related to processes regulating nutrition, body composition and growth, and heart, liver, thyroid or kidney dysfunction ...
COSTANTINO, Luca, D. Barlocco
openaire +3 more sources