Results 131 to 140 of about 5,420 (161)

LEAP2 is a more conserved ligand than ghrelin for fish GHSRs

Biochimie, 2022
ABSTRACT Recently, liver-expressed antimicrobial peptide 2 (LEAP2) was identified as an endogenous competitive antagonist and an inverse agonist of the ghrelin receptor GHSR. However, its functions in lower vertebrates are not well understood.
Hao-Zheng Li, Xiao-Xia Shao, Ya-Fen Wang, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo   +5 more
openaire   +2 more sources

The new mechanism of Ghrelin/GHSR-1a on autophagy regulation

Peptides, 2020
Autophagy is associated with several diseases. In recent years, accumulating evidence has suggested that ghrelin pathway exerts a protective effect by regulating autophagy. This review aims to assess the potential role and use of ghrelin as a new treatment for obesity, cardiovascular diseases, nonalcoholic fatty liver disease (NFALD), neurodegenerative
Ming-Jie, Yuan, Tao, Wang
openaire   +2 more sources

Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity

Bioorganic and Medicinal Chemistry Letters, 2010
Piperazine-bisamide analogs were discovered as partial agonists of human growth hormone secretagogue receptor (GHSR) in a high throughput screen. The partial agonists were optimized for potency and converted into antagonists through structure-activity relationship (SAR) studies.
Julio C Medina, Holger Beckmann
exaly   +3 more sources

Investigation of GHSR and GHRL Methylation in Colorectal Cancer

Epigenomics, 2018
To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC) tissues and healthy adjacent mucosa.Methylation was assessed with methylation-sensitive high-resolution melting.GHSR was significantly hypermethylated in CRC tissues than in healthy mucosa (p 
Coppedè, Fabio, Stoccoro, Andrea, Lazzarotti, Alessandro, Spisni, Roberto, Migliore, Lucia   +4 more
openaire   +3 more sources

Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders

Frontiers in Nutrition
Ghrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning.
Yunxiao Ma, Qihui Yan, Ping Wang, Weiying Guo, Lu Yu   +4 more
exaly   +4 more sources

Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications

Current Issues in Molecular Biology
Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression.
Jing Chen, Bingyuan Ji, Ji Bingyuan
exaly   +4 more sources

Associations of GHSR gene polymorphisms with chicken growth and carcass traits

Molecular Biology Reports, 2009
Ghrelin receptor (GHSR), or growth hormone secretagogue receptor, modulates many physiological effects by binding to its ligand and therefore is a candidate gene for chicken production performance. In this study, five polymorphisms (four SNP and a 'GGTACA' indel) of GHSR gene were genotyped in a F(2) full sib chicken population to investigate their ...
Meixia, Fang, Qinghua, Nie, Chenlong, Luo, Dexiang, Zhang, Xiquan, Zhang   +4 more
openaire   +2 more sources

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis

Gene, 2020
Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia ...
Coppede F., Stoccoro A., Nicoli V., Gallo R., De Rosa A., Guida M., Maestri M., Lucchi M., Ricciardi R., Migliore L.   +9 more
openaire   +3 more sources

Diagnostic values of GHSR DNA methylation pattern in breast cancer

Breast Cancer Research and Treatment, 2012
DNA methylation patterns have been recognised as cancer-specific markers with high potential for clinical applications. We aimed at identifying methylation variations that differentiate between breast cancers and other breast tissue entities to establish a signature for diagnosis.
Sandeep Kumar, Botla, Amin Moghaddas, Gholami, Mahdi, Malekpour, Evgeny A, Moskalev, Mahdi, Fallah, Pouria, Jandaghi, Ali, Aghajani, Irina S, Bondar, Ramesh, Omranipour, Fatemeh, Malekpour, Abbas, Mohajeri, Azin Jahangiri, Babadi, Özgür, Sahin, Vladimir V, Bubnov, Hossein, Najmabadi, Jörg D, Hoheisel, Yasser, Riazalhosseini   +16 more
openaire   +2 more sources

Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens

Molecular Biology Reports, 2014
The ghrelin (GHRL), ghrelin receptor (GHSR), and insulin-like growth factor 1 receptor (IGF1R) genes have crucial effects on body weight (BW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR) in many species. However, few studies on associations of GHRL, GHSR, and IGF1R with BWG, FI, and FCR have been reported in chickens.
Sihua, Jin, Sirui, Chen, Huifeng, Li, Yue, Lu, Guiyun, Xu, Ning, Yang   +5 more
openaire   +2 more sources