Results 101 to 110 of about 431,797 (248)

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

open access: yesComprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang   +5 more
wiley   +1 more source

Hydrogel Micro-/Nanosphere Coated by a Lipid Bilayer: Preparation and Microscopic Probing

open access: yesGels, 2017
The result of polymeric nanogels and lipid vesicles interaction—lipobeads—can be considered as multipurpose containers for future therapeutic applications, such as targeted anticancer chemotherapy with superior tumor response and minimum side effects. In
Sarah Rahni, Sergey Kazakov
doaj   +1 more source

Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density

open access: yes, 2015
The electrostatic complexation between DOTAP-DOPC unilamellar liposomes and an oppositely charged polyelectrolyte (NaPA) has been investigated in a wide range of the liposome surface charge density.
Bordi, Federico   +3 more
core   +3 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

open access: yesMedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang   +10 more
wiley   +1 more source

Unique thermal behavior of sphingomyelin species with nonhydroxy and 2-hydroxy very-long-chain (C28-C32) PUFAs

open access: yesJournal of Lipid Research, 2013
In rat germ cells and spermatozoa, sphingomyelin (SM) contains molecular species with nonhydroxy (n) and 2-hydroxy (h) very-long-chain polyunsaturated fatty acids (V), the most abundant being SMs with (n- and h-) 28:4n-6, 30:5n-6, and 32:5n-6 as acyl ...
Daniel A. Peñalva   +4 more
doaj   +1 more source

Electroformation in a flow chamber with solution exchange as a means of preparation of flaccid giant vesicles

open access: yes, 2008
A recently described technique (Estes and Mayer, Biochim. Biophys. Acta 1712 (2005) 152--160) for the preparation of giant unilamellar vesicles (GUVs) in solutions with high ionic strength is examined.
Akashi   +40 more
core   +1 more source

A chloride channel from human placenta reconstituted into giant liposomes

open access: yesAmerican Journal of Obstetrics and Gynecology, 1995
Ion channels play important roles in epithelial transport, but they are difficult to access for conventional electrophysiologic studies in intact placenta. The purpose of this work was to explore the suitability of purified trophoblast plasma membrane as a source of ion channels for reconstitution in artificial lipid membranes.Human placental brush ...
Riquelme, Gloria   +3 more
openaire   +3 more sources

Phase separation on giant liposomes prepared by gel-assisted swelling.

open access: yesBiophysical Journal, 2023
Khasey Keith, Yifei Wang, Sheereen Majd
semanticscholar   +1 more source

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling

open access: yesFrontiers in Cellular Neuroscience, 2017
α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson’s disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and ...
Audrey T. Medeiros   +4 more
doaj   +1 more source

Mechanical power is maximized during contractile ring-like formation in a biomimetic dividing cell model

open access: yesNature Communications
The spatial and temporal dynamics of forces in cells coordinate essential behaviors like division, polarization, and migration. While intracellular signaling initiates contractile ring assembly during cell division, how mechanical forces coordinate ...
Ryota Sakamoto, Michael P. Murrell
doaj   +1 more source

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