Results 101 to 110 of about 431,797 (248)
Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang +5 more
wiley +1 more source
Hydrogel Micro-/Nanosphere Coated by a Lipid Bilayer: Preparation and Microscopic Probing
The result of polymeric nanogels and lipid vesicles interaction—lipobeads—can be considered as multipurpose containers for future therapeutic applications, such as targeted anticancer chemotherapy with superior tumor response and minimum side effects. In
Sarah Rahni, Sergey Kazakov
doaj +1 more source
Salt-induced reentrant stability of polyion-decorated particles with tunable surface charge density
The electrostatic complexation between DOTAP-DOPC unilamellar liposomes and an oppositely charged polyelectrolyte (NaPA) has been investigated in a wide range of the liposome surface charge density.
Bordi, Federico +3 more
core +3 more sources
Progress in RNA‐Targeted Therapeutics for Human Diseases
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
In rat germ cells and spermatozoa, sphingomyelin (SM) contains molecular species with nonhydroxy (n) and 2-hydroxy (h) very-long-chain polyunsaturated fatty acids (V), the most abundant being SMs with (n- and h-) 28:4n-6, 30:5n-6, and 32:5n-6 as acyl ...
Daniel A. Peñalva +4 more
doaj +1 more source
A recently described technique (Estes and Mayer, Biochim. Biophys. Acta 1712 (2005) 152--160) for the preparation of giant unilamellar vesicles (GUVs) in solutions with high ionic strength is examined.
Akashi +40 more
core +1 more source
A chloride channel from human placenta reconstituted into giant liposomes
Ion channels play important roles in epithelial transport, but they are difficult to access for conventional electrophysiologic studies in intact placenta. The purpose of this work was to explore the suitability of purified trophoblast plasma membrane as a source of ion channels for reconstitution in artificial lipid membranes.Human placental brush ...
Riquelme, Gloria +3 more
openaire +3 more sources
Phase separation on giant liposomes prepared by gel-assisted swelling.
Khasey Keith, Yifei Wang, Sheereen Majd
semanticscholar +1 more source
α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson’s disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and ...
Audrey T. Medeiros +4 more
doaj +1 more source
The spatial and temporal dynamics of forces in cells coordinate essential behaviors like division, polarization, and migration. While intracellular signaling initiates contractile ring assembly during cell division, how mechanical forces coordinate ...
Ryota Sakamoto, Michael P. Murrell
doaj +1 more source

