Results 11 to 20 of about 1,083 (145)

Surgical Management of Giant Prolactinomas: A Descriptive Study

International Journal of Endocrinology, 2023
Introduction. Giant prolactinoma (GP) is a rare pituitary lactotropic cell tumor larger than 4 cm in its widest dimension, and is less likely than a smaller prolactinoma to achieve prolactin normalization on dopamine agonist (DA) monotherapy.
Michelle D. Lundholm, Divya Yogi-Morren, Kevin M. Pantalone, Pablo F. Recinos, Varun R. Kshettry, Pratibha P. R. Rao   +5 more
doaj   +4 more sources

Status epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report [PDF]

Journal of Medical Case Reports, 2019
Background Dopamine agonists are the standard first-line medical therapy for prolactinoma. We report a rare case of giant prolactinoma with a first epileptic seizure due to rapid reduction of the tumor as a complication of dopamine agonist therapy.
Motofumi Koguchi, Yukiko Nakahara, Ryo Ebashi, Atsushi Ogata, Shoko Shimokawa, Jun Masuoka, Tatsuya Abe   +6 more
doaj   +2 more sources

Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome [PDF]

Case Reports in Endocrinology, 2018
Multiple endocrine neoplasia (MEN) type 1 syndrome is an autosomal dominant disorder caused by germline mutations in MEN1 gene, characterized by tumours in endocrine and nonendocrine organs.
Chandrika Jayakanthi Subasinghe, Noel Somasundaram, Pathmanathan Sivatharshya, Lalana Devi Ranasinghe, Márta Korbonits   +4 more
doaj   +2 more sources

Giant prolactinoma, germline BRCA1 mutation, and depression: a case report [PDF]

Journal of Medical Case Reports, 2018
Background Giant prolactinomas are very rare pituitary tumors that may exhibit an aggressive behavior and present with a life-threatening condition. Case presentation A 25-year-old white woman was admitted to our hospital with a headache, psychomotor ...
Rita Bettencourt-Silva, Joana Queirós, Josué Pereira, Davide Carvalho   +3 more
doaj   +2 more sources

Pituitary apoplexy of a giant prolactinoma during pregnancy

Gynecological Endocrinology, 2021
Prolactinomas are a common cause of sexual dysfunction and infertility. We aimed, through this case report, to illustrate the difficulties of management of women with giant prolactinoma, especially in cases of desire of pregnancy.A 30-year-old woman was referred to our department for secondary amenorrhea. Investigations showed a prolactin level of 5168 
Taïeb Ach, Maha Kacem, Koussay Ach
exaly   +3 more sources

Identification of a novel somatic mutation of POU6F2 by whole‐genome sequencing in prolactinoma

Molecular Genetics & Genomic Medicine, 2019
Background Pituitary adenomas (PAs) are one of the most common intracranial tumors; approximately half of PAs are prolactin (PRL)‐secreting PAs (prolactinomas). The genetic alterations prevalent in prolactinomas are unknown.
Yazhou Miao, Chuzhong Li, Jing Guo, Hongyun Wang, Lei Gong, Weiyan Xie, Yazhuo Zhang   +6 more
doaj   +2 more sources

Multimodal management of giant prolactinoma with extensive amyloid spherule deposition: a case report with review of the literature [PDF]

Endocrine Journal
Amyloid spherule-containing prolactinomas are rare entities associated with dopamine agonist (DA) resistance and aggressive behaviour. We report a giant amyloid spherule-containing prolactinoma with a substantial tumour burden and markedly elevated ...
Aysel Unver Ozkahraman, Merve Korkmaz Yilmaz, Huseyin Karatay, Sidar Bagbudar, Ebubekir Akpinar, Buruc Erkan, Mehmet Karagulle, Mesut Yilmaz, Mutlu Niyazoglu, Esra Hatipoglu   +9 more
doaj   +2 more sources

A case of giant prolactinoma, initially misdiagnosed as sinonasal neuroendocrine carcinoma

Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, 2015
Giant prolactinomas are defined as pituitary tumors greater than 4 cm, often associated with very high prolactin level (>1000 ng/mL). They are relatively rare tumors and can present differently from typical prolactinomas.
Kashif Munir
exaly   +3 more sources

Obstructive Hydrocephalus, Fifth Nerve and Hypothalamus Involvement: Acute Presentation of a Giant Prolactinoma

Clinical Medicine Insights: Case Reports, 2012
Introduction Pituitary tumors from lactotrope cells account for about 40% of all functioning pituitary cancers. Men tend to present with a larger, more invasive and rapid growth prolactinomas than women, possibly because hypogonadism features are less ...
Naji Aljohani
exaly   +4 more sources

Giant Prolactinoma in Men: Clinical Features and Therapeutic Outcomes [PDF]

Hormone and Metabolic Research, 2018
AbstractThe aim of the study was to evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas). A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed ...
Juan J Diez, Carles Villabona, Pedro Iglesias   +2 more
exaly   +3 more sources