Results 51 to 60 of about 1,083 (145)

Molecular Basis of Aggressiveness in Pituitary Adenomas and Its Association With the Immune Microenvironment

International Journal of Genomics, Volume 2025, Issue 1, 2025.
Background: Pituitary adenomas (PAs) are common intracranial tumors, and their aggressive phenotype exhibits a poor prognosis. We aimed to explore the aggressive feature of PAs and discover novel diagnostic markers. Method: The datasets of GSE260487 and GSE169498, which contained invasive and noninvasive samples, were downloaded from the Gene ...
Xiaoyan Chen, Jingnan Wang, Qianqian Guo, Minghua Ren   +3 more
wiley   +1 more source

Advancements in Molecular Diagnosis and Pharmacotherapeutic Strategies for Invasive Pituitary Adenomas

Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.
ABSTRACT Background The overwhelming majority of pituitary tumors consist of pituitary adenomas (PAs), which have recently also been termed pituitary neuroendocrine tumors (PitNETs). Clinically significant PAs occur in approximately one in every 1000 individuals, while other types of pituitary tumors, such as craniopharyngiomas and pituicytomas, are ...
Dingkai Xu, Ling Wang, Maohua Zheng
wiley   +1 more source

Visual morbidity in macroprolactinoma: A retrospective cohort study

Clinical Endocrinology, Volume 101, Issue 6, Page 648-658, December 2024.
Abstract Objective The management of visual field damage in patients with macroprolactinomas is a major therapeutic challenge. We aimed to study the visual morbidity associated with macroprolactinoma and its outcomes following medical and surgical treatment. We aimed to identify predictors of visual recovery. Methods We retrospectively reviewed patient'
Yaron Rudman, Hadar Duskin‐Bitan, Hiba Masri‐Iraqi, Amit Akirov, Ilan Shimon   +4 more
wiley   +1 more source

The cavernous sinus: An anatomic study with clinical implication

Laryngoscope Investigative Otolaryngology, Volume 9, Issue 2, April 2024.
This manuscript examines the gross anatomy of the region and highlights important surgical implications drawn from these as well as previously published studies. Herein, I perform a review of the historical scientific, anatomic, clinical, and surgical literature and additionally perform and describe cadaveric dissections revealing novel details about ...
Myles L. Pensak
wiley   +1 more source

Peptide receptor radionuclide therapy for aggressive pituitary tumors: a monocentric experience

Endocrine Connections, 2019
In aggressive pituitary tumors (PT) showing local invasion or growth/recurrence despite multimodal conventional treatment, temozolomide (TMZ) is considered a further therapeutic option, while little data are available on peptide receptor radionuclide ...
G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari, S Cannavò   +10 more
doaj   +1 more source

Transsphenoidal surgery for prolactinomas in male patients: a retrospective study

Asian Journal of Andrology, 2023
Male patients with prolactinomas usually present with typical hyperprolactinemia symptoms, including sexual dysfunction and infertility. However, clinical factors related to sexual dysfunction and surgical outcomes in these patients remain unclear.
Wei-Jie Su, Hong-Cai Cai, Guo-Chen Yang, Ke-Jun He, Hong-Lin Wu, Yi-Bing Yang, Hong-Xing Tang, Li-Xuan Yang, Chun-Hua Deng   +8 more
doaj   +1 more source

Cerebrospinal fluid rhinorrhoea in young women after 6.5 years of therapy giant prolactinoma with Cabergolin

Эндокринная хирургия, 2018
Cerebrospinal fluid (CSF) leak is a rare complication in of the prolactinomas treatment with dopamine agonists. In most cases CSF leak develops within the first three months of treatment starting.
Ludmila I. Astafyeva, Boris A. Kadashev, Pavel L. Kalinin, Maxim A. Kutin, Yuliya G. Sidneva, Denilbek B. Ismailov, Ilya V. Chernov, Dina A. Yatsenko, Larisa K. Dzeranova   +8 more
doaj   +1 more source

Endoscopic Transsphenoidal Surgery of Pituitary Adenomas: Preliminary Results of the Neurosurgery Service of Hospital Cristo Redentor

Brazilian Neurosurgery, 2023
Objective The transsphenoidal surgery is a safe and effective technique to manage different skull base pathologies, such as pituitary adenomas. The purpose of the present study is to describe the initial experience with endoscopic transsphenoidal surgery
Gerson Perondi, Afonso Mariante, Fernando Azambuja, Gabriel Frizon Greggianin, Wanderson William dos Santos Dias, Giulia Pinzetta   +5 more
doaj   +1 more source

Phosphorylation of PBK at Thr9 by CDK5 correlates with invasion of prolactinomas

CNS Neuroscience &Therapeutics, Volume 30, Issue 2, February 2024.
The level of pPBK‐T9 is highly expressed in invasive PitNETs, CDK5 could promote the phosphorylation of PBK‐T9 through the p38 MAPK signaling pathway to promote cell proliferation and EMT progression. we revealed that this signaling axis in PitNETs, CDK5/PBK/p38 MAPK, promoted the tumorigenesis of PitNETs.
Qiuyue Fang, Changxiaofeng Liu, Ding Nie, Jing Guo, Weiyan Xie, Yazhuo Zhang   +5 more
wiley   +1 more source

Idiopathic Granulomatous Mastitis

The Breast Journal, Volume 2024, Issue 1, 2024.
Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this condition is noninfectious, but many cases are noted to be associated with Corynebacterium species.
Christina Dilaveri, Amy Degnim, Christine Lee, Daniel DeSimone, Dan Moldoveanu, Karthik Ghosh, Neslihan Cabioglu   +6 more
wiley   +1 more source