Results 201 to 210 of about 114,906 (281)

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Microscopic Evidence for a Stargate Structure in the Giant Virus, Samba Virus. [PDF]

Microscopy and Microanalysis, 2016
Jason R. Schrad, Jônatas S. Abrahão, Juliana R. Cortines, Kristin N. Parent   +3 more
openaire   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Advantages and Limits of Metagenomic Assembly and Binning of a Giant Virus. [PDF]

mSystems, 2020
Schulz F, Andreani J, Francis R, Boudjemaa H, Bou Khalil JY, Lee J, La Scola B, Woyke T.   +7 more
europepmc   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Conservative taxonomy and quality assessment of giant virus genomes with GVClass. [PDF]

Npj Viruses
Pitot TM, Brůna T, Schulz F.
europepmc   +1 more source

Disseminated Invasive Aspergillosis in a Young Patient With Chronic Alcohol Use and Seemingly Preserved Immunocompetence: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Invasive aspergillosis, though typically seen in immunocompromised patients, can also affect immunocompetent individuals and mimic pulmonary malignancy. This case highlights the importance of considering fungal infections in the differential diagnosis of chronic respiratory symptoms, particularly in patients with risk factors such as heavy ...
Kumail Khandwala, Hiba Sawliha Syed, Shayan Sirat Maheen Anwar, Sehar Suleman, Khabab Abbasher Hussien Mohamed Ahmed   +4 more
wiley   +1 more source

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Epilepsia Open, Volume 11, Issue 1, Page 347-362, February 2026.
Abstract Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of patients with drug‐resistant epilepsy, thereby optimizing their treatment with anti‐seizure medications ...
Jenni Kyyriäinen, Adriana Della Pietra, Mastaneh Torkamani‐Azar, Mireia Gómez‐Budia, Polina Abushik, Nataliia Novosolova, Henri Eronen, Omar Narvaez, Ekaterina Paasonen, Vera Lezhneva, Anssi Pelkonen, Liudmila Saveleva, Antti Huotarinen, Ilya Belevich, Eija Jokitalo, Kuopio Epilepsy Center Epilepsy Surgery Group, Leena Jutila, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Jussi Tohka, Olli Gröhn, Reetta Kälviäinen, Tarja Malm, Alejandra Sierra   +24 more
wiley   +1 more source

GiantHunter: accurate detection of giant virus in metagenomic data using reinforcement-learning and Monte Carlo tree search. [PDF]

Bioinformatics
Qu F, Peng C, Guan J, Wang D, Sun Y, Shang J.   +5 more
europepmc   +1 more source

Structural and Proteomic Characterization of the Initiation of Giant Virus Infection. [PDF]

Cell, 2020
Schrad JR, Abrahão JS, Cortines JR, Parent KN.   +3 more
europepmc   +1 more source