Results 171 to 180 of about 21,469 (223)

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Novel Z-DNA binding domains in giant viruses. [PDF]

J Biol Chem
Romero MF, Krall JB, Nichols PJ, Vantreeck J, Henen MA, Dejardin E, Schulz F, Vicens Q, Vögeli B, Diallo MA.   +9 more
europepmc   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists. [PDF]

Nat Commun
Bessenay A, Bisio H, Belmudes L, Couté Y, Bertaux L, Claverie JM, Abergel C, Jeudy S, Legendre M.   +8 more
europepmc   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Evolution of exploitation and replication of giant viruses and virophages. [PDF]

Virus Evol
Del Arco A, Fischer MG, Becks L.
europepmc   +1 more source

Intelligent Molecular Recognition in Hydrogen‐Bond‐Mediated Supramolecular Polyhedra

SmartMat, Volume 7, Issue 3, June 2026.
This perspective highlights the construction of sophisticated hydrogen‐bonded supramolecular polyhedra from macrocycles by emulating the hierarchical assembly of ferritin and viral capsids, and summarizes their selective recognition of individual guest molecules as well as the synergistic encapsulation of multiple species, demonstrating their potential
Ran‐Qi Chen, Tuo‐Yu Zhou, Yu Wang, Huang Wu   +3 more
wiley   +1 more source

Aosta Valley animal cancer registry: A collaborative initiative for monitoring cancer burden in animals

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Animal cancer registry data are important for monitoring animal health, for prevention and research in veterinary medicine, and for comparative oncology. Since people and animals share the same environment and are exposed to many common risk factors, cancer patterns in animals may have a sentinel function for human health.
Claudio Trentin, Giulio Barigelletti, Caterina Abate, Giovanna Michela Villa, Emilio Bazzocchi, Lorenzo Domenis, Silvia Vuillermoz, Magda Giulia Santini, Barbara Avuzzi, Alessandro Borgini, Giovanna Tagliabue   +10 more
wiley   +1 more source

Novel High-Quality Amoeba Genomes Reveal Widespread Codon Usage Mismatch Between Giant Viruses and Their Hosts. [PDF]

Genome Biol Evol
Willemsen A, Manzano-Marín A, Horn M.
europepmc   +1 more source

Zoonotic risks in urban areas: Prevalence of helminth parasites in urban populations of Lissachatina fulica in Sarawak, Malaysia

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background The giant African land snail (Lissachatina fulica), an invasive species with significant medical, agricultural and economic importance, is abundant in urban areas of Kota Samarahan, Sarawak. The proximity between humans and the snail may increase the risk of pathogen transmission.
Farid Farhan Mohd Nor, Nur Aniyah Sulaiman, Tiffany Junior Singgah Iddie, Dayang Norafizan Awang Chee, Madinah Adrus   +4 more
wiley   +1 more source