Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
The national challenge: raising standards, supporting schools - overview of the gifted and talented pilot programme (National Strategies: national challenge) [PDF]
, 2009 "This is the first in a series of resources to be published by the National Strategies to help schools in this National Challenge pilot to accelerate the progress and enrich the learning of gifted and talented (G&T) pupils.
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Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
A Bibliometric Analysis of Creativity Studies Within Giftedness
Education SciencesThe relationship between intelligence and creativity has remained a focus of research for nearly 75 years. The primary objective of this study was to examine the current state of research on creativity in the context of giftedness and to identify ...
Feyzullah Şahin
doaj +1 more source
Frontiers in Psychology, 2022 Considerable evidence supports that preschool education is a milestone stage for children. Nonetheless, systematic preschool gifted education programs rarely exist in public elementary schools.
Ahmed Mohamed, Hala Elhoweris
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
"Student voice: : perceptions of the Gifted Kids Programme alumni 2000-2007 : a thesis presented in partial fulfillment of the requirements for the degree of Master in Education at Massey University [PDF]
, 2009 Whilst there is some international research available regarding withdrawal programmes and out-of-school options for gifted students, there is little information internationally or nationally surrounding a withdrawal model that students can attend over an
Clark, Deborah
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The national challenge: raising standards, supporting schools - gifted and talented pilot programme. User guide and element 1: leading and managing improvement for gifted and talented education (National Strategies: national challenge) [PDF]
, 2009 "A booklet to help schools involved in the National Challenge Gifted and Talented (G&T) pilot to support leadership and management of improvement for gifted and talented education. This booklet contains Element 1 of a set of three.
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source