Results 61 to 70 of about 60,062 (314)

Knowledge and practice of adults towards different weight loss methods

Rwanda Medical Journal
INTRODUCTION: Obesity has become a major public health issue worldwide. This study assessed knowledge and practices regarding various pharmacological and non-pharmacological weight loss approaches among 393 adults in Iraq.
Raghad O. Aldabbagh, Marwah A. Alshorbaji, Yahya M. Alsabbagh   +2 more
doaj   +1 more source

Under Pressure: Gifted Students’ Vulnerabilities, Stressors, and Coping Mechanisms Within a High Achieving High School

Behavioral Sciences
This qualitative study explores the interactions among gifted students’ vulnerabilities, stressors, supports, and coping mechanisms at a public, high-achieving residential high school.
Addison Helsper, Lillian DeShon, Laura E. Boylan, James Galliher, Lisa DaVia Rubenstein   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Preliminary Study of Satisfaction with University Mentoring in High-Intellectual-Ability Secondary Students: Instrument Validation and Association with Key Learning Processes

Education Sciences
Academic satisfaction is positioned as a fundamental psychological construct with regard to academic success, linked to well-being and cognitive engagement.
Miryam Martínez-Izaguirre, Jon Peña-San José, Alexander Álvarez-González   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Mediating Role of Satisfying Basic Psychological Needs on The Relationship Between Parenting Styles and Mental Health in Gifted Students

آموزش بهداشت و ارتقاء سلامت ایران, 2017
Background and Objective: Living up based on authentic goals, meaning and striving to achieve personal growth have been defined as mental health. Many studies have addressed the effect of personal and contextual factors on the mental health.
Somayeh Sadati Firoozabadi, Ghavam Moltafet   +1 more
doaj  

Preparing special educators to teach second language to students with learning disabilities in the United Arab Emirates: an experimental study

Cogent Education
Consistently, it has been reported that children with disabilities struggle to acquire literacy skills. Although there is evidence that students with learning disability are not given requisite support in classrooms, there is limited research on training
Maxwell Peprah Opoku, Maria Efstratopoulou, Fatima Alkatheeri, Haseena Shah, Lydia Haitham Kasem, Amina Khurshid, Eleana Charalambous, Ashraf Moustafa   +7 more
doaj   +1 more source

Matematik Öğretmenlerinin Üstün Zekâlılar Hakkındaki Görüşlerinin İncelenmesi: Bir Metafor Çalışması

Sakarya University Journal of Education, 2018
Metaforlar ile birzihinsel şema başka bir zihinsel şema altında açıklanmasına olanak sağlayangüçlü zihinsel yapılardır. Metaforlar yardımı ile bir kişinin herhangi bir konuhakkındaki görüş ve düşünceleri anlaşılabilir.
Mehmet Kırmızı, Kamuran Tarım
doaj   +1 more source