Results 161 to 170 of about 8,138,603 (288)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

open access: yesAngewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler   +20 more
wiley   +1 more source

BarnebyLives: An R package to create herbarium specimen labels and clean spreadsheets

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Premise Accessioning herbarium specimens is labor intensive, yet remains vital for research in ecology, evolution, and conservation. As institutional support for herbaria declines, efficient tools are needed to streamline this process. The R package BarnebyLives was developed to assist collectors by supplementing collection notes, verifying ...
Reed Clark Benkendorf, Jeremie B. Fant
wiley   +1 more source

Hyperostosis frontalis interna: Observed patterns, prevalence, and dementia associations in older adults

open access: yesThe Anatomical Record, EarlyView.
Abstract Hyperostosis frontalis interna (HFI) is a frequently underrecognized condition characterized by overgrowth of the frontal endocranium, most commonly observed in post‐menopausal women. Although its etiology remains unclear, hormonal influences and a possible relationship with neurocognitive changes have been proposed.
Danielle Felsberg   +5 more
wiley   +1 more source

Recent modified air-assisted liquid–liquid microextraction applications for medicines and organic compounds in various samples: A review

open access: yesOpen Chemistry, 2022
Azooz Ebaa Adnan   +3 more
doaj   +1 more source

Getting (un)wasted: How planning failures generate consumer waste across resources: Time, money, goods, and energy

open access: yesConsumer Psychology Review, EarlyView.
Abstract Past research suggests that people exhibit robust waste aversion. However, many consumers routinely feel that they waste not only goods but also time, money, energy, and emotion and would be hard‐pressed to imagine their lives otherwise. Why does consumer waste persist? In this paper, we first propose a definition for consumer waste.
Marissa A. Sharif, Cait Lamberton
wiley   +1 more source

Effects of an Organic Acid Blend on Growth Performance, Redox Homeostasis, and Intestinal Microbiota of Broilers in an Antibiotic‐Free Production System Under Winter Environmental Challenges

open access: yesAnimal Research and One Health, EarlyView.
Schematic summary of the effects of organic acids on growth performance and gut health‐related parameters in broilers. ABSTRACT This study was conducted to evaluate the effects of an organic acid blend on growth performance, redox homeostasis, and intestinal microbiota of broilers raised in an antibiotic‐free system during the winter season in China ...
Rong‐Hui Huang   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy