Results 1 to 10 of about 11,036 (199)

Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells

Cells, 2023
Iron homeostasis is considered a key factor in human metabolism, and abrogation in the system could create adverse effects, including cancer. Moreover, 6-gingerol is a widely used bioactive phenolic compound with anticancer activity, and studies on its ...
Dong Young Kang, Sanghyeon Park, Kyoung Seob Song, Se Won Bae, Jeong-Sang Lee, Kyoung-Jin Jang, Yeong-Min Park   +6 more
doaj   +2 more sources

10-Gingerol Increases Antioxidant Enzymes and Attenuates Lipopolysaccharide-Induced Inflammation by Modulating Adipokines in 3T3-L1 Adipocytes

Antioxidants
Background: Obesity increases reactive oxygen species production and alters adipokines levels, resulting in a low-grade chronic inflammation state, which contributes to tissue metabolic dysfunction.
María Elizabeth Preciado-Ortiz, Erika Martínez-López, José Pedraza-Chaverri, Omar Noel Medina-Campos, Roberto Rodríguez-Echevarría, Samantha Desireé Reyes-Pérez, Juan José Rivera-Valdés   +6 more
doaj   +2 more sources

Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes

RSC Advances, 2023
Gingerols, mainly [6]-gingerol (6G), [8]-gingerol (8G), and [10]-gingerol (10G), are the functional and specific pungent phytochemicals in ginger. However, poor oral bioavailability limits their applications owing to extensive metabolism.
Chanjuan Chen, Xintong Chen, Q. Mo, Jie Liu, Xin-Sheng Yao, X. Di, Zifei Qin, Liangliang He, Zhi-Hong Yao   +8 more
semanticscholar   +3 more sources

6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation

Folia Histochemica et Cytobiologica, 2023
INTRODUCTION: Sepsis is characterized by an overactive inflammatory response. Acute lung injury (ALI) is the most common type of organ injury in sepsis, with high morbidity and mortality.
Quanli Pan, Peng Liu, Min Wan
doaj   +2 more sources

Research progress on the function and application of gingerol

Liang you shipin ke-ji, 2020
Gingerol is one of the bioactive ingredients in ginger，which plays an important role in the medicinal efficacy of ginger.In this study，the chemical structure and composition of gingerol were introduced，and the advantages and disadvantages of different ...
SUN Lu, ZHAO Xiao-yan, ZHU Yun-ping, ZHANG Xiao-wei, LIU Hong-kai, ZHU Hai-tao   +5 more
doaj   +2 more sources

6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway

Scientific Reports
6-Gingerol, the main bioactive compound of ginger, has antioxidant, anti-inflammatory, anti-cancer and neuroprotective effects. However, it is unclear whether 6-Gingerol has protective effects against hepatic ischemia/reperfusion (I/R) injury.
Qiwen Yu, Jiye Li, Mengwei Cui, Chaopeng Mei, Qianqian He, Xiaoxiao Du   +5 more
doaj   +2 more sources

The ginger polyphenol 6-gingerol elicits minimal changes in an ex vivo human gut microbiome [PDF]

Frontiers in Nutrition
Ginger (Zingiber officinale) has a long history of use in traditional medicine and the modern world to alleviate health conditions, particularly those related to indigestion and nausea. Gingerols are phenolic bioactive compounds found in ginger.
Karley K. Mahalak, Adrienne B. Narrowe, Jenni Firrman, Johanna M. S. Lemons, LinShu Liu   +4 more
doaj   +2 more sources

Studies on the anticonvulsant potential of 6-gingerol, an active ingredient of ginger rhizome [PDF]

Frontiers in Pharmacology
Ginger (Zingiber officinale), due to its diverse therapeutic properties, continues to attract researchers’ attention. One of these properties is its anticonvulsant activity, which, as our previous studies have shown, may result from the presence of 6 ...
Dorota Nieoczym, Wirginia Kukula-Koch, Małgorzata Szafarz, Jonathan Vuong, Anna Grenda, Dominik Tarabasz, Mateusz Pierog, Marta Marszalek-Grabska, Michal Szulc, Camila V. Esguerra, H. Steve White, Kinga Gawel   +11 more
doaj   +2 more sources

Gingerol Enhances Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells Impaired by Oxidative Stress via the Wnt/β-Catenin Pathway [PDF]

Journal of Functional Biomaterials
Background and Objectives: Dental pulp stem cells (DPSCs) possess significant regenerative potential; however, oxidative stress impairs their viability and osteogenic differentiation.
Abdullah Alqarni, Jagadish Hosmani, Naif Abdulrhman Al Fadhil, Nasser Zafer Abdullah AlHamid, Hassan Ahmed Assiri, Rayan Mohammedfarooq Meer, Bandar Yahya Alshehri   +6 more
doaj   +2 more sources

Evaluation the cytotoxic effect of Fe3O4@Glu-Gingerol on lung adenocarcinoma cell line (A549) with biological mechanisms

Heliyon, 2023
The use of nanotechnology products with supermagnetic properties for targeted delivery of drugs has gained attention recently. Due to the anticancer features of Gingerol, the major phenolic compound from Ginger, this study aims to prepare Fe3O4@Glucose ...
Tabarek Abdulrazaq Alkinani, Fahimeh Abedini Bajgiran, Mohammad Rezaei, Ali Motamedi Maivan, Fatemeh Jafari Golrokh, Mona Bejarbaneh, Sara Rezaei Mojdehi, Sahar Gorji, Reza Ghasemian, Mohammad Dashtban Jalil Pustin Sarai, Fatemeh Akbari, Somayeh Dehghan, Fatemeh Mirzaee, Noor Hussein Abdulrahman, Ali Salehzadeh   +14 more
doaj   +2 more sources