Results 71 to 80 of about 2,402 (156)

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Expression of Arg-Gingipain RgpB Is Required for Correct Glycosylation and Stability of Monomeric Arg-Gingipain RgpA fromPorphyromonas gingivalisW50 [PDF]

Infection and Immunity, 2005
ABSTRACTArg-gingipains are extracellular cysteine proteases produced by the gram-negative periodontal pathogenPorphyromonas gingivalisand are encoded byrgpAandrgpB. Three Arg-gingipains, heterodimeric high-molecular-mass Arg-gingipain HRgpA comprising the α-catalytic chain and the β-adhesin chain, the monomeric soluble Arg-gingipain comprising only the
Minnie, Rangarajan, Ahmed, Hashim, Joseph, Aduse-Opoku, Nikolay, Paramonov, Elizabeth F, Hounsell, Michael A, Curtis   +5 more
openaire   +2 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Matrix Metalloproteinases in Periodontal and Peri‐Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

Journal of Periodontal Research, EarlyView.
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa, Lorne M. Golub, Julie Toby Thomas, Pietro Leone, Sukumaran Anil, Veli‐Jukka Uitto   +5 more
wiley   +1 more source

Effects of orthodontic treatment on , gingipains and gingival inflammation

European Journal of Inflammation, 2023
Purpose : To assess the effects of orthodontic treatment on the changes of Porphyromonas gingivalis ( P.g ) and gingipains as well as gingival inflammation.
Lin Wang, Zhigang Wang, Mei Zhang, Shuiqing Xiao, Qiushuang Gao   +4 more
doaj   +1 more source

Type II cleaved gingipain adhesins act in bacterial invasion [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Gingipains are multi domain peptidases that are primary virulence factors expressed by the keystone periodontal disease pathogen P. gingivalis. The adhesion regions of these proteases are multi-domain complexes that are comprised of a number of modules that belong to the type 1 (T1) family of gingipain adhesins (also known as cleaved adhesin domains ...
Jinlong Gao, Daniele Vicari, Nan Li, Charles Collyer   +3 more
openaire   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

Frontiers in Cellular and Infection Microbiology, 2019
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodontitis and related
Lu Jia, Nannan Han, Juan Du, Lijia Guo, Zhenhua Luo, Yi Liu   +5 more
doaj   +1 more source

Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion

International Journal of Oral Science, 2023
While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), the underlying mechanisms remain unclear.
Yuka Shiheido-Watanabe, Yasuhiro Maejima, Shun Nakagama, Qintao Fan, Natsuko Tamura, Tetsuo Sasano   +5 more
doaj   +1 more source

Porphyromonas Gingivalis Survives In BMECs By Kgp Inhibiting Lysosomal Acidification

International Dental Journal
Aim or purpose: This study aimed to investigate Porphyromonas gingivalis (P. gingivalis) persistence in human brain microvascular endothelial cells (BMECs), its impact on cellular lysosomal acidification and regulatory mechanisms, given that brain ...
Angu Li, Xiaolin Tang
doaj   +1 more source