Results 81 to 90 of about 2,402 (156)

Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. [PDF]

PLoS Pathogens, 2009
Periodontitis is an inflammatory disease of the supporting structures of the teeth caused by, among other pathogens, Prevotella intermedia. Many strains of P.
Michal Potempa, Jan Potempa, Tomasz Kantyka, Ky-Anh Nguyen, Katarzyna Wawrzonek, Surya P Manandhar, Katarzyna Popadiak, Kristian Riesbeck, Sigrun Eick, Anna M Blom   +9 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 256-269, February 2026.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Gingipains fromPorphyromonas gingivalis— complex domain structures confer diverse functions [PDF]

European Journal of Microbiology and Immunology, 2011
Gingipains, a group of arginine or lysine specific cysteine proteinases (also known as RgpA, RgpB and Kgp), have been recognized as major virulence factors in Porphyromonas gingivalis. This bacterium is one of a handful of pathogens that cause chronic periodontitis.
N, Li, C A, Collyer
openaire   +2 more sources

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

OmpA_C‐Like Domain of PorE Is Essential for PorE Function in the Type IX Secretion System (T9SS) of Porphyromonas gingivalis and Some T9SS Cargo Proteins Are Secreted in a PorE‐Independent Manner

Microbiology and Immunology, Volume 70, Issue 1, Page 15-26, January 2026.
ABSTRACT The periodontal pathogen Porphyromonas gingivalis secretes gingipains, highly hydrolytic proteases, to the cell surface or external environment via a type IX secretion system (T9SS). PorE is one of the T9SS component proteins essential for gingipain secretion. It consists of four domains: TPR, WD40, CRD, and OmpA_C‐like.
Takashi Tominaga, Hideharu Yukitake, Paul D. Veith, Dhana G. Gorasia, Takao Ayuse, Takuro Sanuki, Eric C. Reynolds, Koji Nakayama, Mariko Naito, Mikio Shoji   +9 more
wiley   +1 more source

Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR

Biological Chemistry, 2004
AbstractHeme utilization inPorphyromonas gingivalisrequires the participation of an outer membrane hemin/hemoglobin receptor, HmuR, the lysine-specific gingipain proteinase (Kgp) and arginine-specific gingipain proteinase (Rgp). In this study, the expression ofhmuR,kgpandrgpAgenes in response to growth with different heme sources was examined by ...
Liu, Xinyan, Sroka, Aneta, Potempa, Jan, Attardo Genco, Caroline   +3 more
openaire   +3 more sources

Prospects for treatment of Porphyromonas gingivalis-mediated disease – immune-based therapy

Journal of Oral Microbiology, 2015
Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth associated with a polymicrobial biofilm (subgingival plaque) accreted to the tooth which results in destruction of the tooth's supporting tissues.
Eric C. Reynolds, Neil O'Brien-Simpson, Tony Rowe, Andrew Nash, Jackie McCluskey, Didier Vingadassalom, Harold Kleanthous   +6 more
doaj   +1 more source

Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

BMC Microbiology, 2009
Background The oral pathogen Porphyromonas gingivalis has been shown to modulate apoptosis in different cell types, but its effect on epithelial cells remains unclear. Results We demonstrate that primary human gingival epithelial cells (HGECs) challenged
Garcia Carlos A, Benakanakere Manjunatha R, Galicia Johnah C, Stathopoulou Panagiota G, Potempa Jan, Kinane Denis F   +5 more
doaj   +1 more source

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

Journal of Immunology Research, 2017
Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial ...
E. S. Rovai, M. Holzhausen
doaj   +1 more source

Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains

Journal of Dental Research, 2003
Cysteine proteinases (gingipains) from Porphyromonas gingivalis are considered key virulence factors of severe periodontitis and host immune evasion. Since expression of intercellular adhesion molecule-1 (ICAM-1) on gingival epithelium is indispensable in polymorphonuclear leukocyte (PMN) migration at the site of periodontitis, we examined the effects
Tada, H., Sugawara, S., Nemoto, E., Imamura, T., Potempa, Jan, Travis, J., Shimauchi, H., Takada, H.   +7 more
openaire   +3 more sources