Results 21 to 30 of about 3,959 (209)

The modulation of hypoxia-inducible factor-1α/plasminogen activator inhibitor-1 axis in human gingival fibroblasts stimulated with cyclosporine A

Journal of the Formosan Medical Association, 2015
The prominent side effect of the immunosuppressive drug cyclosporine A (CsA) is gingival overgrowth. Hypoxia-inducible factor (HIF)-1α regulates a wide variety of profibrogenic genes, which are closely associated with tissue fibrosis.
Chung-Hung Tsai, Shiuan-Shinn Lee, Fu-Mei Huang, Cheng-Chia Yu, Shun-Fa Yang, Yu-Chao Chang   +5 more
doaj   +1 more source

Establishment of Rat Model of Drug-Induced Gingival Overgrowth Induced by Continuous Administration of Phenytoin

Journal of Pharmacological Sciences, 2005
It is well-known that the anticonvulsant drug, phenytoin (PHT), induces gingival overgrowth as a side effect. The mechanism of PHT-induced gingival overgrowth, however, is not well understood.
Yasuka Tamamori, Yukihiko Tamura, Tsuneyoshi Yamazaki, Keiichi Ohya   +3 more
doaj   +1 more source

Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth?

Journal of the Formosan Medical Association, 2013
Gingival overgrowth can be induced in patients treated with cyclosporine-A (CsA), an immunosuppressant often used following organ transplantation. A pre-existing rat model designed to mimic CsA-induced gingival overgrowth in humans was used to test the ...
Ching-Hwa Gau, Hsiao-Pei Tu, Yu-Tang Chin, Rebecca Y.A. Chen, Martin Ming-Jen Fu, Earl Fu   +5 more
doaj   +1 more source

Using saliva nitrite and nitrate levels as a biomarker for drug induced gingival overgrowth

Frontiers in Cellular and Infection Microbiology, 2015
Aim: Drug-induced gingival overgrowth has a multifactorial nature and the pathogenesis is still uncertain. It has been suggested that Nitric Oxide (NO) might play a role in the pathogenesis of drug-induced gingival overgrowth due to the contribution of ...
Erkan eSukuroglu, Güliz Nigar Güncü, Kamer eKılınc, Feriha eCaglayan   +3 more
doaj   +1 more source

Upregulation of Slug expression by cyclosporine A contributes to the pathogenesis of gingival overgrowth

Journal of the Formosan Medical Association, 2016
Gingival overgrowth occurs as a side effect of systemic medication with immunosuppressant cyclosporine A (CsA). Slug, a master regulator of epithelial–mesenchymal transition, is dramatically upregulated in a variety of fibrotic diseases.
Chung-Hung Tsai, Cheng-Chia Yu, Shiuan-Shinn Lee, Hui-Chieh Yu, Fu-Mei Huang, Yu-Chao Chang   +5 more
doaj   +1 more source

Epithelial to Mesenchymal Transition in Gingival Overgrowth [PDF]

The American Journal of Pathology, 2010
Epithelial to mesenchymal transition (EMT) occurs normally in development. In pathology, EMT drives cancer and fibrosis. Medication with phenytoin, nifedipine, and cyclosporine-A often causes gingival overgrowth. Based partly on the histopathology of gingival overgrowth, the present study investigates the hypothesis that EMT could contribute to its ...
Siddika Selva, Sume, Alpdogan, Kantarci, Alan, Lee, Hatice, Hasturk, Philip C, Trackman   +4 more
openaire   +2 more sources

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Localized Longstanding Chronic Inflammatory Gingival Overgrowth - A Case Report

King Khalid University Journal of Health Sciences, 2016
We report a young patient who presented with longstanding gingival swelling. Based on the clinical, radiological, and histopathology findings following excision, a diagnosis of localized longstanding chronic inflammatory gingival overgrowth was made ...
Shankar T. Gokhale, Saurabh Chaturvedi, Shashit Shetty Bavabeedu, N Raghavendra Reddy, Astha Agrawal   +4 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Treatment and two-year follow-up of a patient with hereditary gingival fibromatosis

Journal of Indian Society of Periodontology, 2011
Hereditary gingival fibromatosis is a rare disorder characterized by various degrees of attached gingival overgrowth. Gingival fibromatosis usually develops as an isolated disorder but can be one feature of a syndrome.
Abhinav Bansal, Sumit Narang, K Sowmya, Nidhi Sehgal   +3 more
doaj   +1 more source