Results 111 to 120 of about 51,810 (321)

Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency

Cell Discovery, 2019
Synthetic biology approach has been frequently applied to produce plant rare bioactive compounds in microbial cell factories by fermentation. However, to reach an ideal manufactural efficiency, it is necessary to optimize the microbial cell factories ...
Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan, Zhihua Zhou   +8 more
semanticscholar   +1 more source

An intestinal bacterial metabolite (M1) of ginseng protopanaxadiol saponins inhibits tumor-induced neovascularization [PDF]

, 2000
The present study demonstrated that an intestinal bacterial metabolite (M1) of protopanaxadiol-type ginsenosides significantly inhibited the growth of implanted tumor and the intrahepatic metastasis by the implantation of a small fragment of colon 26-L5 ...
Hasegawa Hideo, Murakami Koji, Murata Jun, Saiki Ikuo, Suda Kazuhito   +4 more
core   +1 more source

Tissue-smashing based ultra-rapid extraction of chemical constituents in herbal medicines [PDF]

, 2014
postprin
Chen, C, Fan, Y, Li, P, Qi, LW, So, KF, Yan, CP   +5 more
core   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1

Molecular Medicine
Background Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.
Yuesong Yin, Hai Hu, Yian Yang, Song Wu
doaj   +1 more source

American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes [PDF]

, 2009
The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content.
Allison, Ron R., Johnke, Roberta M., Lee, Tung-Kwang, O'Brien, Kevin F., Sheng, Chao, Wang, Tao, Wang, Weidong   +6 more
core   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus

Molecular Neurobiology, 2020
Ginsenoside Rg1 is efficient to prevent or treat mental disorders. However, the mechanisms underlying the effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD) are still not known.
Zhengrong Zhang, Zhu-jin Song, Fengming Shen, Pan Xie, Juan Wang, Aisong Zhu, Guoqi Zhu   +6 more
semanticscholar   +1 more source

Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases [PDF]

, 2010
Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity of IR applied in medicine, agriculture, industry, and the
Chao Sheng, Grdina DJ, Kevin F. O'Brien, Kitts DD, Roberta M. Johnke, Ron R. Allison, Sidi M. Benhabib, SPSS, Tao Wang, Tung-Kwang Lee, Weidong Wang   +10 more
core   +3 more sources

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source