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Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis
Thrombosis Research, 2014Derived from the root of Panax ginseng C.A.Mey, Panax notoginsenosides (PNS) is a widely used herbal medicine to treat atherothrombotic diseases in Asian medicine. Ginsenoside Rg1 is one of the main compounds responsible for the pharmaceutical actions of PNS.
Qi, Zhou +9 more
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The American Journal of Chinese Medicine, 2006
Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
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Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum. The systems not only allowed sensitive detection of G-Rb1 at the level as low as 20 ng/ml and of G-Rg1 at 300 ng/ml, but showed strong ...
Zhi, Chao +2 more
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Neuroprotective Effects and Brain Transport of Ginsenoside Rg1
Chinese Journal of Natural Medicines, 2009Aim Ginsenoside Rg1, one of the major ingredients of Panax notoginseng saponins (PNS), has been proven to possess protective effects on the central nerve system (CNS). However, whether ginsenoside Rg1 could efficiently be transported through the blood brain barrier to elicit its neuroprotective effects remains still unclear. The present study was thus
Rui WANG +5 more
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Preparations of ginsenoside Rg1 immunogen and125I-labeled antiğen
Journal of Radioanalytical and Nuclear Chemistry Articles, 1996This work began with the side chain of ginsenoside Rg1 which was acetylized with Ac2O-Pyr and oxidized by OsO4 and NaIO4 to give ginsenoside Rg1 aldehyde(2), which was further converted into an unsaturated ester(3) by Wittig-Horner reaction. The unsaturated ester(3) was treated with N2H4 and HNO2 to yield Rg1 azide(4) which was directly conjugated with
Mei Congbiao +3 more
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Modification and stability of ginsenoside Rg1 PEG
China Journal of Chinese Materia Medica, 2012OBJECTIVE To study the stability of ginsenoside Rg1 before and after being modified by PEG (PEG-Rg1) in isolated rat stomachs. METHOD SD rats, after 18 h of fasting, were randomly divided into the Rg1 group and the PEG-Rg1 group. Rg1 stomach perfusion fluid and PEG-Rg1 infusion fluid were accurately extracted and injected into their stomachs in vitro ...
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Acta pharmacologica Sinica, 2001
To compare the effect of ginsenoside Rg1 and its metabolite Rh1 on proinflammatory cytokines and their mRNA expression by THP-1 cells.Human peripheral blood mononuclear cells (PBMC) were incubated with Rg1 and Rh1 at concentrations of 0.1, 1, 10, and 100 mg/L, and the cell proliferation was measured 24 h after incubation.
Y, Wang +5 more
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To compare the effect of ginsenoside Rg1 and its metabolite Rh1 on proinflammatory cytokines and their mRNA expression by THP-1 cells.Human peripheral blood mononuclear cells (PBMC) were incubated with Rg1 and Rh1 at concentrations of 0.1, 1, 10, and 100 mg/L, and the cell proliferation was measured 24 h after incubation.
Y, Wang +5 more
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Feasibility study of ginsenoside Rg1 administrated via intranasal route
China Journal of Chinese Matera Medica, 2010To study the feasibility of ginsenoside Rg1 administrated from nasal route.The safty of ginsenoside Rg1 was evaluated by testing cilia movement of the in situ toad palate model. The stability of ginsenoside Rg1 to nasal enzymes and pH was evaluated by HPLC method.
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Ginsenoside RG1 and corticosteroid receptors in rat brain.
Endocrinologia japonica, 1987Old (28 months) male Wistar rats were treated chronically for two weeks with ginsenoside Rg1 or with vehicle delivered via sc implanted Alzet mini-pumps (rate of ginsenoside release 2.4 micrograms/0.5 microliter/h). The number of Type 1 corticosterone-preferring receptor sites (CR) and Type 2 glucocorticoid receptors (GR) was measured in the cytosol of
de Kloet, E R +4 more
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Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice
Immunopharmacology and Immunotoxicology, 2013Recent study reports that Korean red ginseng reduces the nasal allergic inflammatory reaction in an allergic murine model. However, the contribution of ginsenoside Rg1 (RG1) and its mechanisms on allergic rhinitis (AR) have not been elucidated. In this study, we evaluated the important activities of RG1 in the ovalbumin (OVA)-induced AR mice.
Hyun-A, Oh +3 more
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Biotechnology Letters, 2012
Ginsenosides Re and Rg1 were transformed by recombinant β-glucosidase (Bgp1) to ginsenosides Rg2 and Rh1, respectively. The bgp1 gene consists of 2,496 bp encoding 831 amino acids which have homology to the glycosyl hydrolase families 3 protein domain.
Lin-Hu, Quan +5 more
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Ginsenosides Re and Rg1 were transformed by recombinant β-glucosidase (Bgp1) to ginsenosides Rg2 and Rh1, respectively. The bgp1 gene consists of 2,496 bp encoding 831 amino acids which have homology to the glycosyl hydrolase families 3 protein domain.
Lin-Hu, Quan +5 more
openaire +2 more sources