Results 191 to 200 of about 6,292 (226)

Therapeutic potential of ginsenoside Rg3 and Rf for Huntington’s disease

In Vitro Cellular & Developmental Biology - Animal, 2021
Ginseng is a popular herbal medicine and known to have protective and therapeutic effects in various diseases. Ginsenosides are active gradients representing the diverse pharmacological efficacy of ginseng. Huntington's disease (HD) is incurable genetic disorder associated with mutant huntingtin (mHtt) aggregation in the central nervous system.
Mijung, Lee, Jae-Jun, Ban, Bo Hee, Won, Wooseok, Im, Manho, Kim   +4 more
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Ginsenoside Rg3 attenuated omethoate-induced lung injury in rats

Human & Experimental Toxicology, 2015
Organophosphorus exposure affects different organs such as the lung, gastrointestinal tract, liver, and brain. The present experiment aimed to evaluate the effect of ginsenoside Rg3 on lung injury induced by acute omethoate poisoning. Rats were administered with omethoate subcutaneously at a single dose of 60 mg/kg, followed by ginsenoside Rg3 (5, 10,
J, Wang, X F, Yu, J J, Zhao, S M, Shi, L, Fu, D Y, Sui   +5 more
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Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

Modern Rheumatology, 2012
To explore whether Rg3, a major and especially potent ginsenoside, modulates human osteoarthritic (OA) chondrocyte senescence.Isolated chondrocytes were cultured in medium containing interleukin-1 beta (IL-1β) with or without Rg3. The expression levels of mRNAs encoding aggrecan (ACAN), a major structural proteoglycan, type II collagen (COL2A1), and ...
Min Wook, So, Eun-Ju, Lee, Han Sang, Lee, Bon San, Koo, Yong-Gil, Kim, Chang-Keun, Lee, Bin, Yoo   +6 more
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Characteristics of Ginsenoside Rg3-Mediated Brain Na+ Current Inhibition

Molecular Pharmacology, 2005
We demonstrated previously that ginsenoside Rg(3) (Rg(3)), an active ingredient of Panax ginseng, inhibits brain-type Na(+) channel activity. In this study, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced Na(+) channel inhibition. We used the two-microelectrode voltage-clamp technique to investigate the effect of Rg(3) on Na(+)
Jun-Ho, Lee, Sang Min, Jeong, Jong-Hoon, Kim, Byung-Hwan, Lee, In-Soo, Yoon, Joon-Hee, Lee, Sun-Hye, Choi, Dong-Hyun, Kim, Hyewhon, Rhim, Sung Soo, Kim, Jai-Il, Kim, Choon-Gon, Jang, Jin-Ho, Song, Seung-Yeol, Nah   +13 more
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Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806

World Journal of Microbiology and Biotechnology, 2011
In the present investigation, we successfully employed a cell-free extract of Esteya vermicola CNU 120806 to convert ginsenoside Rg3 to Rh2. Three important factors including pH, temperature and substrate concentration were optimized for the preparation of Rh(2). The optimal condition was obtained as follows: 50°C, pH 5.0 and substrate concentration of
Jingang, Hou, Jianjie, Xue, Chunyan, Wang, Lei, Liu, Dongliang, Zhang, Zhen, Wang, Wei, Li, Yinan, Zheng, Changkeun, Sung   +8 more
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Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514

Phytochemistry, 2008
Ginseng saponin, the most important secondary metabolite in ginseng, has various pharmacological activities. Many studies have been directed towards converting major ginsenosides to the more active minor ginsenoside, Rg3. Due to the difficulty in preparing ginsenoside Rg3 enzymatically, the compound has been mainly produced by either acid treatment or ...
Le-Qin, Cheng, Ju Ryun, Na, Myun Ho, Bang, Myung Kyum, Kim, Deok-Chun, Yang   +4 more
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[Fungal biotransformation of ginsenoside Rg3].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2009
Ginsenosides are important bioactive compounds in Ginseng. Sugar chains of ginsenosides are closely related to the bioactivity. Rare ginsenosides can be achieved by modifying sugar chains through biotransformation. Samples of Ginseng root soils, collected from Changbai Mountain, were used to screen active microorganism which can transform total ...
Wu, Xiuli, Wang, Yan, Zhao, Wenqian, Zhang, Yixuan   +3 more
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Ginsenoside Rg3 improves cyclophosphamide-induced immunocompetence in Balb/c mice

International Immunopharmacology, 2019
Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to improve the immunocompetence of cancer patients undergoing chemotherapy. This study was designed to elucidate the immunoenhancement effects of Rg3 in immunosuppressed mice induced by cyclophosphamide (CTX) treatment.
Xiao, Liu, Zhaojian, Zhang, Jinghua, Liu, Yu, Wang, Qian, Zhou, Siwei, Wang, Xiaoying, Wang   +6 more
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Ginsenoside Rg3 improves cardiac mitochondrial population quality: Mimetic exercise training

Biochemical and Biophysical Research Communications, 2013
Emerging evidence indicates exercise training could mediate mitochondrial quality control through the improvement of mitochondrial dynamics. Ginsenoside Rg3 (Rg3), one of the active ingredients in Panax ginseng, is well known in herbal medicine as a tonic and restorative agent.
Mengwei, Sun, Chenglin, Huang, Cheng, Wang, Jianheng, Zheng, Peng, Zhang, Yangshu, Xu, Hong, Chen, Weili, Shen   +7 more
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Synthesis of ginsenoside Rg3, a minor constituent of Ginseng Radix

Carbohydrate Research, 1997
Glycosylation of 12beta-acetoxy-dammar-24-en-3beta,20(S)-diol (4), with hepta-O-acetyl-alpha-sophorosyl bromide (5) under catalysis by Ag2CO3 or Ag2O afforded a chromatographically unseparated mixture of the alpha- and beta-linked octaacetates 6 and 7 in an approximately 2.5:1 ratio. After deprotection and chromatographic purification, the free alpha- (
V P, Anufriev, G V, Malinovskaya, V A, Denisenko, N I, Uvaròva, G B, Elyakov, S I, Kim, N I, Baek   +6 more
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