Results 71 to 80 of about 20,751 (192)

Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Frontiers in Veterinary Science, 2022
In broiler chicks, Escherichia coli lipopolysaccharide is a prominent cause for inflammatory damage and loss of immune homeostasis in broiler chicks. Ginsenosides have been shown to have anti-inflammatory and antioxidant effects. However, it has not been
Shicheng Bi, Yiwen Qu, Jianjian Shao, Jianrong Zhang, Weihao Li, Li Zhang, Jingxuan Ni, Liting Cao   +7 more
doaj   +1 more source

20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways

Journal of Ginseng Research, 2023
Background Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiac remodeling as well as heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovascular diseases, its efficacy and specific molecular ...
Hong-lin Xu, Haifeng Miao, Guanghong Chen, Guoyong Zhang, Y. Hua, Yuting Wu, Tonghong Xu, Xin Han, Changlei Hu, Mingjie Pang, Leyi Tan, Bin Liu, Yingchun Zhou   +12 more
semanticscholar   +1 more source

Anti-Metastasis Effects of Ginsenoside Rg3 in B16F10 Cells

Journal of Microbiology and Biotechnology, 2015
Ginsenoside Rg3 is a bioactive ginseng constituent that has been reported to have diverse pathological and physiological effects, including anti-inflammatory and anti-metastatic activities. Metastasis is one of the most important factors involved in patients with melanoma.
Seul Gi, Lee, Young Jin, Kang, Ju-Ock, Nam   +2 more
openaire   +2 more sources

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells

Journal of Ginseng Research, 2018
Background: Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung ...
Jae Sik Yu, Hyun-Soo Roh, Kwan-Hyuck Baek, Seul Lee, Sil Kim, Hae Min So, Eunjung Moon, Changhyun Pang, Tae Su Jang, Ki Hyun Kim   +9 more
doaj   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, EarlyView.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization

Journal of Ginseng Research, 2018
Background: Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages.
Saeromi Kang, Soo-Jin Park, Ae-Yeon Lee, Jin Huang, Hae-Young Chung, Dong-Soon Im   +5 more
doaj   +1 more source

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, EarlyView.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source

The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Frontiers in Pharmacology, 2021
Background: For advanced non-small cell lung cancer (NSCLC) patients, first-line chemotherapy is the main treatment in the clinic despite its efficacy is limited and adverse effects are always inescapable.
Ze Peng, Wen Wen Wu, Ping Yi
doaj   +1 more source

Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis

Chinese Medical Journal, 2008
Ginsenosides are main components extracted from ginseng, and ginsenoside Rg3 is one of the most important parts. Ginsenoside Rg3 has been found to inhibit several kinds of tumor growth and metastasis. The present study was undertaken to investigate the effect of ginsenoside Rg3 on human ovarian cancer metastasis and the possible mechanism.The ...
Tian-Min, Xu, Man-Hua, Cui, Ying, Xin, Li-Ping, Gu, Xin, Jiang, Man-Man, Su, Ding-Ding, Wang, Wen-Jia, Wang   +7 more
openaire   +2 more sources