Results 71 to 80 of about 25,297 (234)

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Anti-metastatic Potential of Ginsenoside Rp1, a Novel Ginsenoside Derivative

Biological and Pharmaceutical Bulletin, 2008
Ginsenoside Rp1 (G-Rp1) is a novel ginseng saponin with a chemopreventive action. In this study, we examined the anti-metastatic activities of G-Rp1 using relevant in vitro assays and in vivo metastasis models. Using a U937 cell-cell adhesion assay, we found that exogenously added G-Rp1 down-regulates beta1-integrin (CD29) activation at concentrations ...
Tae Yoon, Park, Myung Hwan, Park, Won Cheol, Shin, Man Hee, Rhee, Dong Wan, Seo, Jae Youl, Cho, Hwan Mook, Kim   +6 more
openaire   +3 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases

Journal of Ginseng Research, 2017
Panax ginseng, also called Asian or Korean ginseng, has long been traditionally used in Korea and China to treat various diseases. The major active ingredients of P. ginseng are ginsenosides, which have been shown to have a variety of therapeutic effects,
Jong-Hoon Kim
semanticscholar   +1 more source

Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials

Journal of Functional Foods, 2020
Ginsenosides, the main active ingredients in Panax ginseng, have been used as an adjuvant to treat diabetes mellitus for many years. Experimental and clinical data emerge to support antidiabetic efficacy for ginsenosides ascribe to their antioxidant ...
Jingwei Shao, Jiali Jiang, Jun-Jie Zou, Mingyue Yang, Fangmin Chen, Yong-jie Zhang, L. Jia   +6 more
semanticscholar   +1 more source

A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitis

iMeta, EarlyView.
Schematic representation showing that 20 (S)‐Rg3 improves mouse NASH. 20(S)‐Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)‐Rg3 activates SPOP. Meanwhile, SPOP attenuates the ATF3‐mediated transcriptional repression of NUPR1 by enhancing the K48‐linked ubiquitination of ATF3.
Yibo Zong, Guo Long, Tiantian Gu, Pan Huang, Yong Tian, Wenwu Xu, Xiheng Hu, Dazun Shi, Lizhi Lu, Tao Zeng   +9 more
wiley   +1 more source

Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota

Journal of Ginseng Research, 2020
Background Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the effects of three prebiotic fibers by targeting gut microbiota on the metabolism of ginsenoside Rb1 in vivo.
Xiaoyan Zhang, Sha Chen, Feipeng Duan, An Liu, Shaojing Li, Wen-liang Zhong, W. Sheng, Jun Chen, Jiang Xu, Shuiming Xiao   +9 more
semanticscholar   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source