Results 181 to 190 of about 27,755 (279)

Radiolabeled Angiopep‐2 Peptide Vector as a Preclinical Platform for Blood–Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The developed DOTA‐Angiopep‐2 conjugate was well tolerated in glioma cells and enabled high‐yield radiolabeling with 177Lu and 161Tb. The 161Tb conjugate showed brain delivery with predominantly renal clearance, supporting a stable radiotheranostic platform for BBB‐targeted glioma therapy and SPECT imaging.
Evgenia Fotou, Adamantia Apostolopoulou, Christina‐Georgia Bika, Maria Giannakopoulou, Danai‐Efraimia Bajwa, Vassilios Moussis, Vassilios Tsikaris, Ioannis P. Gerothanassis, George A. Alexiou, Penelope Bouziotis, Andreas G. Tzakos   +10 more
wiley   +1 more source

Implant Deviation Assessment in Static and Dynamic Guidance: An In Vitro Study. [PDF]

Cureus
Kachouh C, Mrad S, Younes R, Tohme H, Ghosn N, Saleh A, Menhall A.   +6 more
europepmc   +1 more source

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
A gut organoid model was developed to study the impact of age‐related changes of the enteric nervous system (ENS) and microbiome on the integrity and trophic capacity of the intestinal epithelial barrier. Organoids reflected in vivo aging features, including altered epithelial integrity and changes in acetylcholine‐related enzyme activity.
Tinh Thi Nguyen, Dennis Schapelhouman, Katharina Fischer, Jia‐Xuan Chen, Mario Dejung, Fridolin Kielisch, Julia Varga, Johannes Piepgras, Matthew Ahn, Oliver Tüscher, Peter Baumann, Sandra Schick, Kristina Endres   +12 more
wiley   +1 more source

Continued norovirus false positivity after FDA clearance of the BioFire FilmArray gastrointestinal panel. [PDF]

Microbiol Spectr
Daley M, Poulter MD, Snavely EA.
europepmc   +1 more source

A systematic review and meta‐analysis of the relative benefit of dual versus single oral hypoglycaemic therapy following diagnosis with type 2 diabetes (T2D)

Diabetic Medicine, Volume 43, Issue 7, July 2026.
Abstract Introduction Achieving and sustaining target glycated haemoglobin (HbA1c) levels is fundamental in the management of type 2 diabetes (T2D). We here aimed to assess whether initial dual oral therapy outperforms monotherapy in reaching glycaemic targets in patients with treatment‐naive or early‐stage T2D.
Mairead Kelly, Sushant Saluja, Hugh Logan Ellis, Sarah Jamil, Martin B. Whyte, Adrian Heald   +5 more
wiley   +1 more source

Glucagon-like Peptide-1 and Dual GIP/GLP-1 Receptor Agonists in Brain: Exploring the Expanding Role and Safety in Neuropsychiatry. [PDF]

Int J Mol Sci
Tudosie AC, Marin LM, Popa SG, Golli AL.
europepmc   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Petrelintide for Weight Management: Two Randomized, Controlled Phase 1 Trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5915-5925, July 2026.
ABSTRACT Aims Petrelintide is a long‐acting amylin analogue in development for weight management. The safety, tolerability, pharmacokinetics, and pharmacodynamics of petrelintide were evaluated in single ascending dose (SAD) and multiple ascending dose (MAD) trials. Materials and Methods Both trials were randomized, placebo‐controlled, and double‐blind.
Minna Brændholt Olsen, Jon Griffin, Ulrike Hövelmann, Stanislava Macura, Berith Fredsted Hagen, Dan Hesse, Tim Heise   +6 more
wiley   +1 more source

Novel evidence for tirzepatide, a dual GLP-1/GIP receptor agonist, to reduce the motivation for cocaine in rodents. [PDF]

EBioMedicine
Knackstedt LA.
europepmc   +1 more source

Semaglutide Treatment in Young Adults Living With Type 2 Diabetes: A Post Hoc Analysis From the SUSTAIN and PIONEER Clinical Trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5787-5802, July 2026.
ABSTRACT Aims Young adults (aged ≤ 40 years) are underrepresented in clinical trials that investigate interventions for those living with Type 2 diabetes (T2D). This study evaluated the efficacy of semaglutide treatment in young adults with T2D by examining the effects on HbA1c and body weight (BW) during the SUSTAIN and PIONEER programmes compared to ...
Francesco Zaccardi, Vanita R. Aroda, Ecenur Guder Arslan, Lars Bardtrum, Jonathan Goldney, Erik Ising, Prachi Priyadarshini, Tommy Slater, Melanie J. Davies   +8 more
wiley   +1 more source

Glucagon-like peptide-1 (GLP-1) levels are associated with acute kidney injury after cardiac surgery. [PDF]

Sci Rep
Szafran A, Kurt B, Pracht J, Zechendorf E, Breuer T, Stoppe C, Marx G, Tacke F, Kahles F, Mossanen JC.   +9 more
europepmc   +1 more source