Results 181 to 190 of about 36,022 (296)

Chronic, but not acute, treatment with GLP-2 and GIP in combination increases glucose absorption in the isolated vascularly perfused rat intestine. [PDF]

Physiol Rep
Galsgaard KD, Cookson TA, Modvig IM, Abba V, Trammell SAJ, Rosenkilde MM, Gasbjerg LS, Sørensen CM, Hartmann B, Holst JJ.   +9 more
europepmc   +1 more source

Automation of the Azapeptide Submonomer Synthesis Method

Journal of Peptide Science, Volume 32, Issue 11, November 2026.
The solid phase submonomer azapeptide synthesis method was automated using a commercially available peptide synthesizer. Key findings for the successful automation included the use of stable isocyanate precursor for the semicarbazone installation step, elimination of all cooling steps, use of a heating block, and use of DMF as solvent.
Tyler G. Hobart, Molly E. Helton, Maxwell O. Bowles, Caroline Proulx   +3 more
wiley   +1 more source

Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism. [PDF]

Nat Metab
Lewis JE, Montaner M, Nuzzaci D, James-Okoro PP, Harada N, Inagaki N, Dodson WS, Knerr PJ, Douros JD, Gribble FM, Reimann F.   +10 more
europepmc   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

Tirzepatide for treatment of postbariatric hypoglycemia after Roux-en-Y gastric bypass: a report of 3 cases. [PDF]

JCEM Case Rep
Milosavljevic J, Meyer C, Levine JA, Sachdev S.   +3 more
europepmc   +1 more source

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6‐Month Claims Database Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9966-9979, November 2026.
ABSTRACT Aims Tirzepatide is a once‐weekly glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of tirzepatide among individuals in a large ...
Theresa Hunter Gibble, Malvika Venkataraman, Donna Mojdami, Carlos Vallarino, Grace Stockbower, Michael Grabner, Mythili Ananth, Karishma Desai   +7 more
wiley   +1 more source

Native Cadmium-Tolerant <i>Trichoderma</i> Associated with the Rhizosphere of <i>Inga</i> sp. and <i>Quararibea</i> sp. in Amazonian Cocoa Agroecosystems of Peru. [PDF]

J Fungi (Basel)
Ramos Armaulia JS, Méndez Fasabi LD, Leiva Espinoza ST, Oliva Cruz SM.   +3 more
europepmc   +1 more source

Retatrutide‐Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10183-10194, November 2026.
ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo, Charles Harris, Yanzhu Lin, Jonathan M. Wilson, Valentina Pirro, Kevin L. Duffin, Melissa K. Thomas, Mark L. Hartman, Ciara O' Neill, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Naveed Sattar, Stephen J. Nicholls   +13 more
wiley   +1 more source

Peptide LKLKLL is a more effective component of <i>Akkermansia muciniphila</i> which regulate glucolipid metabolism through GLP-1/GIP dual modulation. [PDF]

Gut Microbes
Li Y, Ye D, Fu C, Huang X, Ma Q, Zhang F, Chen G, Song P, Kong C, Wu J, Wu H, Qiao J, Yang J.   +12 more
europepmc   +1 more source

Body Composition Remodelling During GLP‐1‐Based Therapy: A Systematic Review and Meta‐Analysis Using a Hierarchical Physiological Framework

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9849-9860, November 2026.
ABSTRACT Background Body composition changes during glucagon‐like peptide‐1 (GLP‐1)‐based therapy remain incompletely characterized, particularly regarding their effects on adiposity, muscle quantity, and muscle quality. We conducted a systematic review and meta‐analysis using a predefined physiological framework to evaluate body composition ...
Maria Luizza Lopes Menezes, Maria Eduarda Güntzel Chiappa, Rodrigo Fuentes Kloss, Marcelo Tuesta, Paula Santos, Alberto Souza Sá Filho, Gaspar R. Chiappa   +6 more
wiley   +1 more source