Results 261 to 270 of about 30,994 (308)

Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists.

Peptides, 2019
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) potentiate glucose-induced insulin secretion and are therefore thought to be responsible for the incretin effect.
L. Gasbjerg, N. Bergmann, Signe Stensen, M. Christensen, M. Rosenkilde, J. Holst, M. Nauck, F. Knop   +7 more
semanticscholar   +1 more source

Pharmacological characterization of mono-, dual- and tri- peptidic agonists at GIP and GLP-1 receptors.

Biochemical Pharmacology, 2020
Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone with physiological roles in adipose tissue, the central nervous system and bone metabolism. While selective ligands for GIP receptor (GIPR) have not been advanced for disease treatment,
Elita Yuliantie, Sanaz Darbalaei, A. Dai, P. Zhao, Dehua Yang, P. Sexton, Ming-Wei Wang, D. Wootten   +7 more
semanticscholar   +1 more source

The role of endogenous GIP and GLP-1 in postprandial bone homeostasis.

Bone, 2020
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to affect bone homeostasis as mediators in the so-called entero-osseous axis.
Mads M Helsted, L. Gasbjerg, A. Lanng, N. Bergmann, Signe Stensen, B. Hartmann, M. Christensen, J. Holst, T. Vilsbøll, M. Rosenkilde, F. Knop   +10 more
semanticscholar   +1 more source

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models.

Neuropharmacology, 2018
Type 2 diabetes is a risk factor for several chronic neurodegenerative disorders such as Alzheimer's or Parkinson's disease. The link appears to be insulin de-sensitisation in the brain. Insulin is an important neuroprotective growth factor.
C. Hölscher
semanticscholar   +1 more source

Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1

Nature Reviews Endocrinology, 2022
Rola Hammoud, D. Drucker
semanticscholar   +1 more source

[Gastric inhibitory polypeptide (GIP) and GIP receptor (GIPR)].

Nihon rinsho. Japanese journal of clinical medicine, 1996
Gastric inhibitory polypeptide, originally isolated from porcine intestine, is a gastrointestinal hormone belonging to the vasoactive intestinal peptide (VIP)/glucagon/secretin family. GIP consists of 42 amino acid residues which is derived by proteolytic processing of a GIP precursor.
K, Yasuda, Y, Seino
openaire   +1 more source

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist

Cell Metabolism, 2022
Irina Velikyan, Olof Eriksson, Ralf Elvert   +2 more
exaly  

Molecular interactions of full-length and truncated GIP peptides with the GIP receptor – A comprehensive review

Peptides, 2020
Mette Marie Rosenkilde, Lærke Smidt Gasbjerg, Wijnand Jacobus Cornelis van der Velden   +2 more
exaly  

GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice

Peptides, 2020
Peter Flatt, Daniel Chappard, Sagar Vyavahare   +2 more
exaly  

Gips

1929
C. Doelter, E. Jänecke
openaire   +1 more source