Results 191 to 200 of about 10,013 (222)

Effects of cloperastine, a non-narcotic antitussive, on the expression of GIRK channels in the brain of methamphetamine-induced hyperactive mice

Indian journal of physiology and pharmacology, 2023
Centrally-acting antitussives with inhibitory effects on G protein-coupled inwardly rectifying potassium (GIRK) channels have been shown to also inhibit methamphetamine-induced hyperactivity in mice. In this study, we examined if cloperastine, which is
F. Soeda, Mizue Kinoshita, Yoshiko Fujieda, K. Takahama   +3 more
semanticscholar   +1 more source

Evidence that GIRK Channels Mediate the DREADD-hM4Di Receptor Activation-Induced Reduction in Membrane Excitability of Striatal Medium Spiny Neurons.

ACS Chemical Neuroscience, 2022
The hM4Di receptor-based chemogenetic DREADD system has been widely used to suppress neuronal activities, which has contributed substantially to the identification of behavior-associated neuronal circuitries including those in the striatum.
Qiang Shan, Qimeng Fang, Yao Tian
semanticscholar   +1 more source

Structural characterization of the mouse Girk genes

Gene, 2002
Cardiac and neuronal G protein-gated potassium (K(G)) channels are activated by neurotransmitters such as acetylcholine, opioids, and dopamine. K(G) channel activation leads to an inhibition of synaptic transmission. K(G) channels are tetrameric complexes formed by assembly of G protein-gated, inwardly-rectifying potassium (K(+)) channel (GIRK ...
Kevin, Wickman, William T, Pu, David E, Clapham   +2 more
openaire   +2 more sources

Effects of Orexin (Hypocretin) on GIRK Channels

Journal of Neurophysiology, 2003
Orexins (hypocretins) are recently discovered excitatory transmitters implicated in arousal and sleep. Yet, their ionic and signal transduction mechanisms have not been fully clarified. Here we show that orexins suppress G-protein–coupled inward rectifier (GIRK) channel activity, and this suppression is likely to lead to neuronal excitation.
Q V, Hoang, D, Bajic, M, Yanagisawa, S, Nakajima, Y, Nakajima   +4 more
openaire   +2 more sources

Heartfelt crosstalk: desensitization of the GIRK current

Nature Cell Biology, 2000
Acetylcholine calms the heartbeat by activating Gi-coupled receptors and G-protein-activated inwardly rectifying potassium (GIRK) channels. It also dampens the GIRK current by reducing PIP2 through Gq-coupled receptors. These two types of receptors seem to be engaged in an intriguingly specific form of crosstalk, which leads to desensitization of the ...
L Y, Jan, Y N, Jan
openaire   +2 more sources

Examining The Effects Of Gallein On Opioid Induced GIRK Currents

Physiology
Opioids are powerful analgesics, but carry a risk of overdose that has become a pressing issue to public health in the United States. Overdose deaths are caused by the opioid-induced shutdown of neuronal circuits that operate unconscious breathing cycles,
Charles Keldsen, Carley Beeman, Kai Bartol, Erica Levitt, Alan V. Smrcka   +4 more
semanticscholar   +1 more source

Structural Insights into GIRK Channel Function

2015
G protein-gated inwardly rectifying potassium (GIRK; Kir3) channels, which are members of the large family of inwardly rectifying potassium channels (Kir1-Kir7), regulate excitability in the heart and brain. GIRK channels are activated following stimulation of G protein-coupled receptors that couple to the G(i/o) (pertussis toxin-sensitive) G proteins.
Ian W, Glaaser, Paul A, Slesinger
openaire   +2 more sources

Optical control of GIRK channels using visible light

Organic & Biomolecular Chemistry, 2017
We have developed the photoswitchable GIRK channel agonistVLOGO, which permits the precise control of GIRK channels using visible light.
Trads, Julie B, Burgstaller, Jessica, Laprell, Laura, Konrad, David B, de la Osa de la Rosa, Luis, Weaver, C David, Baier, Herwig, Trauner, Dirk, Barber, David M   +8 more
openaire   +3 more sources

GIRK Channel Plasticity and Implications for Drug Addiction

2015
Drugs of abuse can "hijack" synaptic plasticity, a physiological basis of learning and memory, establishing maladaptations that can promote drug addiction. A wealth of data supports the existence and importance of neuroadaptations in excitatory neurotransmission upon drug exposure.
Ezequiel, Marron Fernandez de Velasco, Nora, McCall, Kevin, Wickman   +2 more
openaire   +2 more sources

New sites of action for GIRK and SK channels

Nature Reviews Neuroscience, 2009
It was recently discovered that two different types of voltage-insensitive K+ channels, G protein-coupled inwardly rectifying K+ (GIRK) and small-conductance Ca2+-activated K+ (SK) channels, are located on dendritic branches, spines and shafts in the postsynaptic densities of excitatory synapses in many central neurons.
Rafael, Luján, James, Maylie, John P, Adelman   +2 more
openaire   +2 more sources