Results 11 to 20 of about 148,838 (258)

Case studies for precision agriculture

open access: yesPlant Protection Science, 2002
The results of spatial variability of plant-available soil nutrients (P, K, Mg) and soil pH are described in this paper. Experiment was realized on the field of area 72 ha (orthic luvisol), located in the area of Český Brod.
J. Šilha   +8 more
doaj   +1 more source

Pharmacoeconomic comparison of insulin glargine and insulin detemir in diabetes mellitus type 2

open access: yesКачественная клиническая практика, 2020
Second generation insulin analogue — insulin glargine 300 UI/ml (GLA-300) — can provide an effective control of Diabetes Mellitus (DM) with minimal risk of hypoglycemic events and prevent of cardiovascular complications or events (CVS).
I. N. Dyakov, S. K. Zyryanov
doaj   +1 more source

Generation of a GLA knock-out human-induced pluripotent stem cell line, KSBCi002-A-1, using CRISPR/Cas9

open access: yesStem Cell Research, 2020
Fabry disease is an X-linked inherited disease caused by a mutation in the galactosidase alpha (GLA) gene. Here, we generated a GLA knock-out cell line (GLA-KO hiPSCs) from normal human-induced pluripotent stem cells (hFSiPS1) using the CRISPR-Cas9 ...
Young-Kyu Kim   +3 more
doaj   +1 more source

Enzymatic properties and clinical associations of serum alpha‐galactosidase A in Parkinson's disease

open access: yesAnnals of Clinical and Translational Neurology, 2023
Objective Recent studies have revealed an association between Parkinson's disease (PD) and Fabry disease, a lysosomal storage disorder; however, the underlying mechanisms remain to be elucidated.
Yasuaki Mizutani   +10 more
doaj   +1 more source

Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway

open access: yesFrontiers in Oncology, 2022
Gastric cancer (GC) ranks as the most common gastrointestinal cancer and is among the leading causes of cancer death worldwide. Glaucocalyxin A (GLA), an entkauranoid diterpene isolated from Rab-dosia japonica var., possesses various bioactivities.
Yanqi Liu   +3 more
doaj   +1 more source

Better glycaemic control and less hypoglycaemia with insulin glargine 300 U/mL vs glargine 100 U/mL : 1-year patient-level meta-analysis of the EDITION clinical studies in people with type 2 diabetes [PDF]

open access: yes, 2018
AimsTo investigate the efficacy and safety of insulin glargine 300U/mL (Gla-300) vs insulin glargine 100U/mL (Gla-100) over 12months in a patient-level meta-analysis, using data from the EDITION studies in people with type 2 diabetes (T2DM).
American Diabetes Association   +20 more
core   +2 more sources

How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases [PDF]

open access: yes, 2016
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular
Breit, Claudia   +9 more
core   +3 more sources

Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation. Part 2. Clinical Efficacy and Safety

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2015
This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®).
V.V. Poltorak   +2 more
doaj   +1 more source

Optimization of Physiological Growth Conditions for Maximal Gamma-Linolenic Acid Production by Cunninghamella Blakesleeana-Jsk2 [PDF]

open access: yes, 2014
Effects of various cultural conditions on biomass, lipid and Gamma-linolenic acid (GLA) production were investigated in the oleaginous fungus Cunninghamella blakesleeana-JSK2 isolated from soil.
Janakiraman, .   +3 more
core   +1 more source

Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study

open access: yesDrug Delivery, 2019
Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its ...
Lili Ren, Jingjing Wang, Guoguang Chen
doaj   +1 more source

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