Results 21 to 30 of about 148,838 (258)

Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation. Part 1. Pharmacokinetic and Pharmacodynamic Aspects

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®).
V.V. Poltorak, N.A. Kravchun, M.Yu. Gorshunska   +2 more
doaj   +1 more source

Simultaneous overexpression of ∆6-, ∆12- and ∆9-desaturases enhanced the production of γ-linolenic acid in Mucor circinelloides WJ11

Frontiers in Microbiology, 2022
Mucor circinelloides WJ11, an oleaginous filamentous fungus, produces 36% lipid of its cell dry weight when cultured in a high C/N ratio medium, however, the yield of γ-linolenic acid (GLA) is insufficient to make it competitive with other plant sources.
Xiuwen Wang, Junhuan Yang, Hassan Mohamed, Hassan Mohamed, Aabid Manzoor Shah, Shaoqi Li, Shuxian Pang, Chen Wu, Futing Xue, Wenyue Shi, Beenish Sadaqat, Yuanda Song   +11 more
doaj   +1 more source

Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells [PDF]

, 2015
Previous studies have demonstrated that gamma-linolenic acid (GLA) is effective against glioma cells under both in vitro and in vivo conditions. In the present study we determined how GLA alone or in combination with irradiation alters the fatty acid (FA)
Antal Otilia Tamara, Ayaydin Ferhan, Balogh Gábor, Hackler László Jr., Hideghéty Katalin, Kitajka Klára, Mán Imola, Puskás László, Péter Mária, Szebeni Gábor, Vigh László   +10 more
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Identification and functional characterization of the first deep intronic GLA mutation (IVS4+1326C>T) causing renal variant of Fabry disease

Orphanet Journal of Rare Diseases, 2022
Background Fabry disease (FD, OMIM #301500) is an X-linked lysosomal disorder caused by the deficiency of α-galactosidase A (α-GalA), encoded by the GLA gene.
Xuantong Dai, Xue Zong, Xiaoxia Pan, Wei Lu, Geng-Ru Jiang, Fujun Lin   +5 more
doaj   +1 more source

One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in people with type 2 diabetes using basal plus meal-time insulin : the EDITION 1 12-month randomized trial, including 6-month extension [PDF]

, 2015
AimsTo evaluate the maintenance of efficacy and safety of insulin glargine 300 U/ml (Gla-300) versus glargine 100 U/ml (Gla-100) in people with type 2 diabetes mellitus (T2DM) using basal plus meal-time insulin for 12 months in the EDITION 1 trial ...
Bolli, G. B., Cissokho, S., Home, P. D., Muehlen-Bartmer, I., Riddle, M. C., Yki-Järvinen, Hannele, Ziemen, M.   +6 more
core   +1 more source

Patient-level meta-analysis of the EDITION 1, 2 and 3 studies : glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus glargine 100 U/ml in people with type 2 diabetes [PDF]

, 2015
AimsTo conduct a patient-level meta-analysis of the EDITION 1, 2 and 3 studies, which compared the efficacy and safety of new insulin glargine 300 U/ml (Gla-300) with insulin glargine 100 U/ml (Gla-100) in people with type 2 diabetes (T2DM) on basal and ...
Bolli, G. B., Brulle-Wohlhueter, C., Glezer, S., Ritzel, R., Roussel, R., Vinet, L., Yki-Järvinen, Hannele   +6 more
core   +1 more source

New Basal Insulin Toujeo Solostar: Increased Therapeutic Potential for the Control of Dysglycaemia in Diabetes Mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
This review examines the new formulation of insulin glargine (recombinant) in the form of injections 300 U/ml (Gla‑300, Toujeo®). Gla‑300 is a next generation basal insulin with a novel formulation of insulin glargin delivering the same amount of insulin,
V.V. Poltorak
doaj   +1 more source

Matrix Gla Protein involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. [PDF]

, 2007
Mature MGP (Matrix gamma-carboxyglutamic acid protein) is known to inhibit soft connective tissues calcification. We investigated its possible involvement in pseudoxanthoma elasticum (PXE), a genetic disorder whose clinical manifestations are due to ...
ANNOVI, Giulia, BORALDI, Federica, C. Vermeer, GHEDUZZI, Dealba, L. Schurgers, PAOLINELLI DEVINCENZI, Chiara, QUAGLINO, Daniela, RONCHETTI, Ivonne   +7 more
core   +1 more source

Herbal therapy for treating rheumatoid arthritis (review) [PDF]

, 2011
Background Herbal medicine interventions have been identified as having potential benefit in the treatment of rheumatoid arthritis (RA). Objectives To update an existing systematic (Cochrane) review of herbal therapies in RA. Search methods
Cameron, Melainie, Chrubasik, Sigrun, Gagnier, Joel J.   +2 more
core   +1 more source