Results 51 to 60 of about 703,544 (344)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Temperature Dependence of Structural Relaxation in Glass-Forming Liquids and Polymers

Entropy, 2022
Understanding the microscopic mechanism of the transition of glass remains one of the most challenging topics in Condensed Matter Physics. What controls the sharp slowing down of molecular motion upon approaching the glass transition temperature Tg ...
Vladimir N. Novikov, Alexei P. Sokolov
doaj   +1 more source

Atomistic modeling of heat treatment processes for tuning the mechanical properties of disordered solids [PDF]

, 2019
We investigate the effect of a single heat treatment cycle on the potential energy states and mechanical properties of metallic glasses using molecular dynamics simulations.
Priezjev, Nikolai V.
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Thermal and structural properties of ZnO-Bi2O3-B2O3 glasses doped with NiO

Eurasian Journal of Physics and Functional Materials, 2022
Among new low melting glasses, bismuthate glass is deemed to have the most potential. Current studies of these glasses focus on the thermal and structural influence of the additional oxide (NiO).
S. Patel, B. Fageria, K. S. Gill, S. Soni, V. N. Mishra   +4 more
doaj   +1 more source

Ordering of the Heisenberg Spin Glass in High Dimensions

, 2003
Ordering of the Heisenberg spin glass with the nearest-neighbor Gaussian coupling is investigated by equilibrium Monte Carlo simulations in four and five dimensions.
B. Coluzzi, D. Imagawa, D. Stauffer, Daisuke Imagawa, F. Matsubara, F. Matsubara, F. Matsubara, H. G. Katzgraber, H. G. Katzgraber, H. Kawamura, H. Kawamura, H. Kawamura, H. Kawamura, H. Kawamura, H. Kawamura, H. Yoshino, Hikaru Kawamura, J. A. Olive, J. R. Banavar, K. Binder, K. Hukushima, K. Hukushima, K. Hukushima, M. Cieplak, P. Reed, P. W. Anderson, R. Botet, S. Endoh, T. Nakamura, W. L. McMillan   +29 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Zero-temperature glass transition in two dimensions

Nature Communications, 2019
Identifying the nature of the glass transition is challenging because relevant experiments or analytical descriptions are hard to achieve. Here, Berthier et al.
Ludovic Berthier, Patrick Charbonneau, Andrea Ninarello, Misaki Ozawa, Sho Yaida   +4 more
doaj   +1 more source

Molecular Dynamics Simulation of Binary liquid mixture Phase Separation and Glass Transition

Chemical Engineering Transactions, 2018
This paper aims to study the phase separation of binary liquid mixture and two-phase glass transition process by using the method of molecular dynamics (MD) simulation.
Meili Li, Xingye Fu
doaj   +1 more source

Influence of the temperature on the dielectric properties of epoxy resins [PDF]

, 2010
Electrical degradation processes in epoxy resins, such as electrical treeing, were found to be dependent on the temperature at which the experiments were carried out.
Chalashkanov, N. M., Dissado, L. A., Dodd, S. J., Fothergill, J.   +3 more
core   +1 more source