Results 201 to 210 of about 102,413 (266)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

MEP glia share molecular features with oligodendrocytes while maintaining a distinct hybrid signature. [PDF]

MicroPubl Biol
Dallo TC, Fontenas L.
europepmc   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Female Mice Show Stronger Time-of-Day Modulation of Astrocytic Ca²⁺ Activity in the Sleep-Regulatory Ventrolateral Preoptic Nucleus. [PDF]

Glia
Bellier FC, Zonca L, Holcman D, Chauveau F, Rouach N, Rancillac A.   +5 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation. [PDF]

Nat Commun
Zhu L, Li R, Qian M, Lv F, Hong H, Li Y, Zhou Y, Li Z, Lei J, Zou W, Guan MX, Zhang Y, Zhao G, Ma H, Gong J, Kang L.   +15 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning. [PDF]

Stem Cell Reports
Ojalvo-Sanz AC, Figueres-Oñate M, Barriola S, Pernia-Solanilla C, Sanchez-Gonzalez R, Delgado-García LM, López-Mascaraque L.   +6 more
europepmc   +1 more source

Glia regulate local retinoic acid levels to specify neuronal specialisation for high-acuity vision

Lahne M, Lungu R, Snorton M, Yoshimatsu T, MacDonald RB.   +4 more
europepmc   +1 more source

Single-Cell Sequencing Analysis Reveals Dysregulated Energy Metabolism and Altered Synaptic Connectivity in the Mouse Retina Following Dark Rearing. [PDF]

Invest Ophthalmol Vis Sci
Zhu Z, Mo E, Dong S, Li Y, Li S, Li H, Zhang X, Zhao YE.   +7 more
europepmc   +1 more source