Results 241 to 250 of about 118,654 (350)

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng, Yinxi Zou, Linwen Liu, Hebo Wang, Zhibing Ai, Shiwen Wu, Qianqian Si, Yiyang Liu, Huanyu Zhou, Haoyao Guo, Qiuyu Yu, Zijue Wang, Mingli Li, Caiyan Liu, Weihai Xu   +14 more
wiley   +1 more source

Case Reports: Three cases of autoimmune glial fibrillary acidic protein astrocytosis in disguise. [PDF]

Front Immunol
Zhao W, Gong L, Wang J, Chen Z, Li Z, Su Q, Shen Y, Zheng C.   +7 more
europepmc   +1 more source

Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear, Christopher Daniel Morrone, Dominic Simpson, Fang Liu, Syed Abid Hussaini, Wai Haung Yu   +5 more
wiley   +1 more source

Study of ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and interleukin-6 levels in an experimental head trauma model in rabbits. [PDF]

Clin Exp Emerg Med
Şahin İ, Kara H, Ünlü A, Uğurluoğlu C, Saraçlıgil B.   +4 more
europepmc   +1 more source

Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers. METHODS The study involved 251 Wake Forest Multi‐Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, magnetic resonance imaging, amyloid positron emission ...
Samuel N. Lockhart, Courtney L. Sutphen, Jordan Tanley, Fernando Gonzalez‐Ortiz, Przemysław R. Kac, Mohamad Habes, Susan R. Heckbert, Nicholas J. Ashton, Michelle M. Mielke, Robert Koeppe, Marc D. Rudolph, Kiran K. Solingapuram Sai, Christopher T. Whitlow, Kevin D. Hiatt, Suzanne Craft, Thomas C. Register, Kathleen M. Hayden, Stephen R. Rapp, Bonnie C. Sachs, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Timothy M. Hughes   +22 more
wiley   +1 more source

Out with prolactin, in with neurofilament light and glial fibrillary acidic protein. [PDF]

Epilepsy Curr
Andrade DM.
europepmc   +1 more source

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source

A case report of autoimmune glial fibrillary acidic protein astrocytopathy combined with Epstein-Barr virus infection. [PDF]

BMC Neurol
An Q, Liu L.
europepmc   +1 more source

Deep cervical lymphatic–venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single‐arm study

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION This study evaluated the efficacy of deep cervical lymphatic–venous anastomosis (dcLVA) for severe Alzheimer's disease (AD). METHODS A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a
Xiaohong Fu, Jing Zhang, Qiuxia Xiao, Tingting Li, Qijun Li, Shaofu Zhang, Wen Zeng, Min Gong, Pan Cai, Zhaojian Deng, Xuan Zhang, Yuanjun Xin, Liping Su, Xiaohe Tian, Kaifeng Wu, Liulin Xiong   +15 more
wiley   +1 more source