Results 21 to 30 of about 91,538 (160)

Immunohistochemical localization of glial fibrillary acidic protein in human glial neoplasms [PDF]

Cancer, 1978
The presence and distribution of glial fibrillary acidic protein in fixed, paraffin embedded tissue were studied in 85 human intracranial neoplasms, using the peroxidase-anti-peroxidase method. In some cases, indirect immunofluorescence of frozen sections was used as well.
M E, Velasco, D, Dahl, U, Roessmann, P, Gambetti   +3 more
openaire   +2 more sources

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. [PDF]

, 2016
The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS).
Chechneva, Olga, Daugherty, Daniel J, Deng, Wenbin, Mayrhofer, Florian   +3 more
core   +1 more source

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]

, 2012
Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S., Handelsman, D.J., Harvey, A.R., Martins, R.N.   +3 more
core   +2 more sources

Exploring the Production of Extracellular Matrix by Astrocytes in Response to Mimetic Traumatic Brain Injury [PDF]

, 2016
Following injury to the central nervous system, extracellular modulations are apparent at the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response
Walker, Addison
core   +2 more sources

Clinical utility of serum glial fibrillary acidic protein in glial neoplasm

Surgical Neurology International, 2022
Background: Glial fibrillary acidic protein (GFAP) is a member of the cytoskeletal protein family and is widely expressed in astroglial and neural stem cells, also in glial tumors such as astrocytoma and Glioblastoma (GBM). Increased GFAP expression and disruption of the blood–brain barrier are the characteristic features of GBM.
Yadav, Nidhi, Mishra, Keshav, B. C., Anil Kumar, Singh, Daljit, Subberwal, Manju   +4 more
openaire   +2 more sources

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Ali, RR, Barber, AC, Graca, AB, Hippert, C, Pearson, RA, Smith, AJ, West, EL   +6 more
core   +1 more source

IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations [PDF]

, 2015
It has been known that activation of the central innate immune system or exposure to stress can disrupt balance of anti-/proinflammatory cytokines. The aim of the present study was to investigate the role of pro- and anti-inflammatory cytokines in the ...
An, Kyungeh, Kim, Kyung Soo, Park, Hyun-Jung, Shim, Hyun-Soo, Shim, Insop, Starkweather, Angela   +5 more
core   +4 more sources

Modelling and Characterization of Glial Fibrillary Acidic Protein [PDF]

Bioinformation, 2015
Glial Fibrillary Acidic Protein (GFAP) is an intermediate-filament (IF) protein that maintains the astrocytes of the Central Nervous System in Human. This is differentially expressed during serological studies in inflamed condition such as Rheumatoid Arthritis (RA).
Deka, Hemchandra, Sarmah, Rajeev, Sharma, Ankita, Biswas, Sagarika   +3 more
openaire   +2 more sources

Glial reaction in the hippocampus after global cardiogenic ischemia [PDF]

, 2001
Many experimental surgerical procedures have been perfomed in the analyse of the phenomenon of brain trophism and plasticity, however undesirable intercorrence can occour leading to specific changes in the results that should be taken into attention.
Chadi, Gerson, Martins, Emerson Fachin
core   +3 more sources