Results 191 to 200 of about 82,505 (300)

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

Diagnostic value of serum brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), plasma viscosity (PV) as well as fibrinogen (FIB) in acute cerebral infarction patients. [PDF]

J Med Biochem
Wang T, Wang F, Dong X, Liu X, Cui Z, Shi Y.   +5 more
europepmc   +1 more source

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng, Yinxi Zou, Linwen Liu, Hebo Wang, Zhibing Ai, Shiwen Wu, Qianqian Si, Yiyang Liu, Huanyu Zhou, Haoyao Guo, Qiuyu Yu, Zijue Wang, Mingli Li, Caiyan Liu, Weihai Xu   +14 more
wiley   +1 more source

Ability of serum glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, and S100B to differentiate normal and abnormal head computer tomography findings in patients with suspected mild or moderate traumatic brain injury [PDF]

, 2016
et al,, Lewis, Lawrence M
core   +1 more source

Clinical, Lab, and Radiological Evolution of an Adult Patient With Unilateral Cortical Lesion in Anti-Myelin Oligodendrocyte Glycoprotein (MOG)-Associated Encephalitis With Seizures and Anti-Glial Fibrillary Acidic Protein (GFAP) Positive Antibodies. [PDF]

Cureus
Papantoniou M, Panagou G, Kanavouras K.
europepmc   +1 more source

Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear, Christopher Daniel Morrone, Dominic Simpson, Fang Liu, Syed Abid Hussaini, Wai Haung Yu   +5 more
wiley   +1 more source

Characterisation of microstructural alterations in a weight drop mTBI rat model : a longitudinal diffusion MRI and histological analysis [PDF]

, 2018
Braeckman, Kim, Caeyenberghs, Karen, Descamps, Benedicte, Pieters, Leen, Vanhove, Christian   +4 more
core  

Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers. METHODS The study involved 251 Wake Forest Multi‐Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, magnetic resonance imaging, amyloid positron emission ...
Samuel N. Lockhart, Courtney L. Sutphen, Jordan Tanley, Fernando Gonzalez‐Ortiz, Przemysław R. Kac, Mohamad Habes, Susan R. Heckbert, Nicholas J. Ashton, Michelle M. Mielke, Robert Koeppe, Marc D. Rudolph, Kiran K. Solingapuram Sai, Christopher T. Whitlow, Kevin D. Hiatt, Suzanne Craft, Thomas C. Register, Kathleen M. Hayden, Stephen R. Rapp, Bonnie C. Sachs, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari, Timothy M. Hughes   +22 more
wiley   +1 more source

Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study [PDF]

, 2015
Chuanfang Wang, Guoyi Gao, Jin Lei, Jiyao Jiang, Junfeng Feng, Qing Mao, Yichao Jin   +6 more
core   +1 more source

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source