Results 21 to 30 of about 319,103 (346)
The adaptive transition of glioblastoma stem cells and its implications on treatments
Signal Transduction and Targeted Therapy, 2021 Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time
Zeyu Wang +4 more
doaj +1 more source
Immunovirotherapy for glioblastoma [PDF]
Cell Cycle, 2013 Virotherapy, the use of oncolytic viruses for cancer therapy, is an old concept currently making substantial clinical progress. Oncolytic viruses, whose tumor selectivity is genetically engineered or naturally occurring, replicate in and kill cancer cells but not normal tissue, and thus have the potential to amplify themselves in situ and spread ...
Hiroaki Wakimoto +2 more
openaire +3 more sources
Management of glioblastoma: State of the art and future directions.
Ca, 2020 Glioblastoma is the most common malignant primary brain tumor. Overall, the prognosis for patients with this disease is poor, with a median survival of
A. Tan +5 more
semanticscholar +1 more source
Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells
BMC Cancer, 2020 Background Glioblastoma is devastating cancer with a high frequency of occurrence and poor survival rate and it is urgent to discover novel glioblastoma-specific antigens for the therapy. Cancer-germline genes are known to be related to the formation and
Fengyu Zhang +5 more
doaj +1 more source
Chinese Medical Journal, 2021 . Background. Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers, such as liver cancer, lung cancer, breast cancer, and others. The potential role of circular RNAs in glioblastoma, however,
Jin-Xu Zhou +8 more
doaj +1 more source
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
New England Journal of Medicine, 2005 BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial
R. Stupp +18 more
semanticscholar +1 more source
Cancer Cell International, 2020 Background Radiotherapy, chemotherapy, and surgery have made crucial strides in glioblastoma treatment, yet they often fail; thus, new treatment and new detection methods are needed.
Fengyu Zhang +4 more
doaj +1 more source
Science Translational Medicine, 2021 SynNotch-CAR T cells durably clear glioblastoma xenografts, overcoming dual challenges of antigen heterogeneity and specificity common to solid tumors. Short circuiting solid tumors Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for ...
Joseph H. Choe +20 more
semanticscholar +1 more source
British Journal of Cancer, 2020 AbstractElevated levels of serum ferritin (SF) are observed in several types of cancer; however, little is known on the association between ferritin and glioma, the most frequent type of human primary brain tumour. Here we report that GBM patients show significantly increased pre-surgical SF levels (i.e. ferritinaemia) within the SF reference range and
Paolo Arosio +9 more
openaire +3 more sources
Glioblastoma: clinical presentation, diagnosis, and management
British medical journal, 2021 • Early symptoms of brain tumours in adults are non-specific, and patients may present multiple times to primary care services before they are referred for investigation. Look for symptoms of raised intracranial pressure (such as headaches exacerbated by
Chris McKinnon +3 more
semanticscholar +1 more source