Results 11 to 20 of about 212,897 (265)
Cancers, 2021 Years ago, glioblastoma lost its second name, multiforme, which possibly was an unfortunate decision given the extraordinary heterogeneity of this overly aggressive primary brain tumor, as effectively exemplified by this Latin adjective [...]
Finocchiaro G., Berzero G.
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Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl-2 and Mcl-1 blockade in preclinical glioblastoma models. [PDF]
FEBS Open BioThe PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Zhao K +23 more
europepmc +2 more sources
Cancers, 2021 Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed +2 more
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Immunovirotherapy for glioblastoma [PDF]
Cell Cycle, 2013 Virotherapy, the use of oncolytic viruses for cancer therapy, is an old concept currently making substantial clinical progress. Oncolytic viruses, whose tumor selectivity is genetically engineered or naturally occurring, replicate in and kill cancer cells but not normal tissue, and thus have the potential to amplify themselves in situ and spread ...
Ning, Jianfang +2 more
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Frontiers in Oncology, 2020 Introduction: O6-methylguanine-methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase (IDH) mutation status are important prognostic factors for patients with glioblastoma.
Fatih Incekara +11 more
doaj +1 more source
Optimization of Tumor Targeting Gold Nanoparticles for Glioblastoma Applications
Nanomaterials, 2022 Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity.
Nicholas C. Allen +3 more
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Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells
BMC Cancer, 2020 Background Glioblastoma is devastating cancer with a high frequency of occurrence and poor survival rate and it is urgent to discover novel glioblastoma-specific antigens for the therapy. Cancer-germline genes are known to be related to the formation and
Fengyu Zhang +5 more
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MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma
Analytical Cellular Pathology, 2022 Objective. Glioblastoma is one of the most common malignant tumors in the brain, and these glioblastoma patients have very poor prognosis. Ferroptosis is involved in the progression of various tumors, including the glioblastoma.
Peng Xu +7 more
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TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells
Redox Biology, 2022 Objective: Glioblastoma is one of the most common intracranial malignant tumors with an unfavorable prognosis, and iron metabolism as well as ferroptosis are implicated in the pathogenesis of glioblastoma.
Kaiqiang Li +11 more
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British Journal of Cancer, 2020 AbstractElevated levels of serum ferritin (SF) are observed in several types of cancer; however, little is known on the association between ferritin and glioma, the most frequent type of human primary brain tumour. Here we report that GBM patients show significantly increased pre-surgical SF levels (i.e. ferritinaemia) within the SF reference range and
Jaksch-Bogensperger, Heidi +9 more
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