Results 31 to 40 of about 319,103 (346)

Optimization of Tumor Targeting Gold Nanoparticles for Glioblastoma Applications

Nanomaterials, 2022
Glioblastoma brain tumors represent an aggressive form of gliomas that is hallmarked by being extremely invasive and aggressive due to intra and inter-tumoral heterogeneity.
Nicholas C. Allen, Rajat Chauhan, Paula J. Bates, Martin G. O’Toole   +3 more
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MGMT gene silencing and benefit from temozolomide in glioblastoma.

New England Journal of Medicine, 2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.
M. Hegi, A. Diserens, T. Gorlia, M. Hamou, N. Tribolet, N. Tribolet, M. Weller, J. Kros, J. Hainfellner, W. Mason, L. Mariani, Jacoline E. C. Bromberg, P. Hau, R. Mirimanoff, J. Cairncross, R. Janzer, R. Stupp   +16 more
semanticscholar   +1 more source

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

Nature Communications, 2022
Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response.
V. Ravi, N. Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, J. Kückelhaus, L. Vollmer, Jonathan M. Goeldner, S. Behringer, F. Scherer, Melanie Boerries, M. Follo, T. Weiss, D. Delev, J. Kernbach, Pamela Franco, N. Schallner, C. Dierks, M. S. Carro, U. Hofmann, C. Fung, R. Sankowski, M. Prinz, Jürgen Beck, Henrike Salié, B. Bengsch, O. Schnell, D. Heiland   +27 more
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A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy

Journal of Experimental & Clinical Cancer Research, 2021
Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to develop durable
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits   +7 more
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MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma

Analytical Cellular Pathology, 2022
Objective. Glioblastoma is one of the most common malignant tumors in the brain, and these glioblastoma patients have very poor prognosis. Ferroptosis is involved in the progression of various tumors, including the glioblastoma.
Peng Xu, Fei-Hang Ge, Wen-Xin Li, Zhen Xu, Xue-Li Wang, Jing-Lan Shen, Ai-Bo Xu, Rong-Rong Hao   +7 more
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Glioblastoma: Changing concepts in the WHO CNS5 classification

Indian Journal of Pathology and Microbiology, 2022
Glioblastoma is the most common malignant central nervous system (CNS) tumor in adults. Acute common clinical symptoms include headache, seizure, behavior changes, focal neurological deficits, and signs of increased intracranial pressure. The classic MRI
Jie Chen, Pengcheng Han, Sonika Dahiya
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Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

JAMA Oncology, 2020
Key Points Question Does programmed cell death 1 immune checkpoint inhibition with nivolumab improve overall survival compared with bevacizumab treatment for patients with recurrent glioblastoma?
D. Reardon, A. Brandes, A. Omuro, P. Mulholland, M. Lim, A. Wick, J. Baehring, M. Ahluwalia, P. Roth, O. Bähr, S. Phuphanich, J. Sepúlveda, P. de Souza, S. Sahebjam, M. Carleton, K. Tatsuoka, C. Taitt, R. Zwirtes, J. Sampson, M. Weller   +19 more
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Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells

Heliyon, 2023
Elucidation of cellular and molecular mechanisms key to glioblastoma growth, self-renewal, survival, and metastasis is important for developing novel therapeutic strategies.
Yan Wang, Jingwei Peng, Chenchen Song, Yining Yang, Tao Qin   +4 more
doaj  

RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis

Biomedicines, 2021
Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown to significantly inhibit the proliferation of prostate cancer cells by targeting the atypical protein kinase RIOK2.
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang   +5 more
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Nature, 2008
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation.
R. McLendon, A. Friedman, D. Bigner, Erwin G. Van Meir, D. Brat, Gena M Mastrogianakis, J. Olson, T. Mikkelsen, N. Lehman, K. Aldape, W. Yung, O. Bogler, J. Weinstein, S. Vandenberg, M. Berger, M. Prados, D. Muzny, M. Morgan, S. Scherer, A. Sabo, L. Nazareth, L. Lewis, O. Hall, Yiming Zhu, Yanru Ren, Omar Alvi, Jiqiang Yao, A. Hawes, S. Jhangiani, G. Fowler, A. Lucas, C. Kovar, Andrew Cree, H. Dinh, J. Santibanez, Vandita Joshi, M. Gonzalez-Garay, Christopher A. Miller, A. Milosavljevic, L. Donehower, D. Wheeler, R. Gibbs, K. Cibulskis, C. Sougnez, T. Fennell, Scott Mahan, Jane Wilkinson, L. Ziaugra, R. Onofrio, Toby Bloom, R. Nicol, K. Ardlie, J. Baldwin, S. Gabriel, E. Lander, L. Ding, R. Fulton, M. McLellan, J. Wallis, D. Larson, Xiaoqi Shi, R. Abbott, L. Fulton, Ken Chen, D. Koboldt, M. Wendl, R. Meyer, Yuzhu Tang, Ling Lin, John R. Osborne, Brian H. Dunford-Shore, T. Miner, K. Delehaunty, C. Markovic, Gary W. Swift, W. Courtney, C. Pohl, S. Abbott, Amy E. Hawkins, Shin Leong, C. Haipek, Heather K. Schmidt, M. Wiechert, T. Vickery, S. Scott, D. Dooling, A. Chinwalla, G. Weinstock, E. Mardis, R. Wilson, G. Getz, W. Winckler, R. Verhaak, M. Lawrence, Michael J. T. O’Kelly, James Robinson, Gabriele Alexe, R. Beroukhim, S. Carter, Derek Y. Chiang, Josh Gould, Supriya Gupta, Joshua M. Korn, C. Mermel, J. Mesirov, S. Monti, Huy L. Nguyen, Melissa Parkin, Michael Reich, Nicolas Stransky, B. Weir, L. Garraway, T. Golub, M. Meyerson, L. Chin, A. Protopopov, Jianhua Zhang, I. Perna, S. Aronson, N. Sathiamoorthy, Georgi Ren, Jun Yao, W. Wiedemeyer, Hyun Soo Kim, Won Kong Sek, Yonghong Xiao, I. Kohane, J. Seidman, P. Park, R. Kucherlapati, P. Laird, L. Cope, J. Herman, D. Weisenberger, F. Pan, D. V. Berg, L. V. Neste, Mingyu Joo, Kornel E. Schuebel, S. Baylin, D. Absher, Jun Z. Li, Audrey M. Southwick, Shannon T. Brady, A. Aggarwal, Tisha Chung, G. Sherlock, J. Brooks, R. Myers, P. Spellman, E. Purdom, L. Jakkula, A. Lapuk, H. Marr, S. Dorton, Gi Choi Yoon, Ju Han, A. Ray, V. Wang, S. Durinck, M. Robinson, Nicholas J. Wang, K. Vranizan, V. Peng, E. V. Name, G. Fontenay, J. Ngai, J. Conboy, B. Parvin, H. Feiler, T. Speed, J. Gray, C. Brennan, N. Socci, A. Olshen, B. Taylor, A. Lash, N. Schultz, B. Reva, Yevgeniy Antipin, Alexey Stukalov, Benjamin E. Gross, E. Cerami, Qingqing Wei, L. Qin, V. Seshan, L. Villafania, Magali Cavatore, L. Borsu, A. Viale, W. Gerald, C. Sander, M. Ladanyi, C. Perou, D. Hayes, M. D. Topal, K. Hoadley, Yuan Qi, S. Balu, Yan Shi, Junyuan Wu, R. Penny, M. Bittner, T. Shelton, E. Lenkiewicz, S. Morris, D. Beasley, Sheri Sanders, A. Kahn, R. Sfeir, Jessica Chen, D. Nassau, Larry Feng, E. Hickey, A. Barker, D. Gerhard, J. Vockley, C. Compton, J. Vaught, P. Fielding, M. Ferguson, C. Schaefer, Jinghui Zhang, Subha Madhavan, K. Buetow, F. Collins, P. Good, M. Guyer, B. Ozenberger, Jane L. Peterson, E. Thomson   +230 more
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