Results 21 to 30 of about 49,717 (158)

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

BMC Biotechnology, 2002
Background We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53.
Ohnishi Ken, Ohnishi Takeo, Takahashi Akihisa   +2 more
doaj   +1 more source

Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells

International Journal of Molecular Sciences, 2021
Deregulated PI3K/AKT/mTOR signalling commonly exists in glioblastoma, making this axis an attractive target for therapeutic manipulation. Given that activation of PI3K/AKT/mTOR promotes tumour growth, metastasis, and resistance to anticancer therapies ...
W. Omeljaniuk, R. Krętowski, W. Ratajczak-Wrona, E. Jabłońska, M. Cechowska-Pasko   +4 more
semanticscholar   +1 more source

Cytotoxic Activity and Phytochemical Screening of Eco-Friendly Extracted Flavonoids from Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep and Trifolium pratense L. Flowers Using HPLC-DAD-MS/HRMS

AppliedChem, 2023
Increasing prospective phytochemical investigations and biological activities on Pueraria lobata and Trifolium pratense flowers exhibited their nutritional (food industry) pharmaceutical (anticancer, anti-inflammatory, anti-microbial, etc.) potentials ...
Saied A. Aboushanab, Vadim A. Shevyrin, Vsevolod V. Melekhin, Elena I. Andreeva, Oleg G. Makeev, Elena G. Kovaleva   +5 more
doaj   +1 more source

Cell growth inhibition and apoptotic effects of a specific anti-RTFscFv antibody on prostate cancer, but not glioblastoma, cells [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
Background: Single chain antibody (scFv) has shown interesting results in cancer immunotargeting approaches, due to its advantages over monoclonal antibodies.
Foroogh Nejatollahi, Payam Bayat, Bahareh Moazen   +2 more
doaj   +1 more source

Cell type-specific Effect of miRZip-21 to Suppress miR-21 in Human Glioma Cell Lines [PDF]

Journal of Cell and Molecular Research, 2019
There are different subtypes of brain tumors, classified according to the origin of the abnormally proliferated glial cells. Glioblastoma multiforma (GBM) is the grade 4 of brain tumors, gliomas, with the least life expectancy.
Hamideh Monfared, Yavar Jahangard, Maryam Nikkhah, Seyed Javad Mirnajafi-Zade, Seyed Javad Mowla   +4 more
doaj   +1 more source

532 nm low-power laser irradiation recovers γ-secretase inhibitor-mediated cell growth suppression and promotes cell proliferation via Akt signaling. [PDF]

PLoS ONE, 2013
The γ-secretase inhibitor (GSI) has been shown to inhibit expression of amyloid beta (Aβ), but GSI also has a side effect of reducing cell survival. Since low-power laser irradiation (LLI) has been known to promote cell survival, we examined whether 532 ...
Yumi Fukuzaki, Haruna Sugawara, Banri Yamanoha, Shinichi Kogure   +3 more
doaj   +1 more source

ACT-11 CLINICAL BENEFIT OF ADD-ON BEVACIZUMAB FOR NEWLY DIAGNOSED GLIOBLASTOMA IN ELDERLY PATIENTS WITH UNRESECTABLE AND POOR PERFORMANCE STATUS

Neuro-Oncology Advances, 2022
Since phase 3 randomized clinical trials failed to show the benefit of bevacizumab(Bev) from the induction therapy, Bev was widely used for the recurrence glioblastoma(GBM) cases.
Kyoichi Tomoto, Yohei Yamamoto, Toshihide Tanaka, Tomoya Suzuki, A. Teshigawara, Jun Takei, Hirokazu Koseki, Ryosuke Mori, Y. Akasaki, Y. Murayama   +9 more
semanticscholar   +1 more source

Comparison Between Folic Acid and gH625 Peptide-Based Functionalization of Fe3O4 Magnetic Nanoparticles for Enhanced Cell Internalization

Nanoscale Research Letters, 2018
A versatile synthetic route based on magnetic Fe3O4 nanoparticle (MNP) prefunctionalization with a phosphonic acid monolayer has been used to covalently bind the gH625 peptide on the nanoparticle surface.
C. Tudisco, M. T. Cambria, A. E. Giuffrida, F. Sinatra, C. D. Anfuso, G. Lupo, N. Caporarello, A. Falanga, S. Galdiero, V. Oliveri, C. Satriano, G. G. Condorelli   +11 more
doaj   +1 more source

Treatment with Tumor-Treating Fields Therapy and Pulse Dose Bevacizumab in Patients with Bevacizumab-Refractory Recurrent Glioblastoma: A Case Series

Case Reports in Neurology, 2016
Patients with bevacizumab-refractory recurrent glioblastoma multiforme (GBM) have a poor prognosis. We propose that instead of continuing on bevacizumab, patients should switch to treatment with Optune™, a novel antimitotic Tumor-Treating Fields ...
George Ansstas, David D. Tran
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source