Results 171 to 180 of about 382,034 (365)
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Depression in patients with high-grade glioma: results of the Glioma Outcomes Project
, 2011 OBJECTIVE: To study the incidence of depression among patients undergoing surgery for high-grade glioma, document factors associated with the presence of depression, and examine the relationship between depression and patient outcome.
Farace, Elana +6 more
core +1 more source
SDS‐CRISPR for Single‐Nucleotide Variant Detection
Advanced Science, EarlyView.Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan +12 more
wiley +1 more source
Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes
, 2018 Ming Zhao,* Mengnan Zhao,* Chen Fu, Yang Yu, Ailing Fu School of Pharmaceutical Sciences, Southwest University, Chongqing, People’s Republic of China *These authors contributed equally to this work Background: Glioma is the most aggressive and ...
Fu A, Zhao M, Fu C, Yu Y
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A Dual‐Channel Synergistic Ultrasensitive Biosensor for Tumor Liquid Biopsy
Advanced Science, EarlyView.ABSTRACT Liquid biopsy technology, which detects circulating tumor DNA (ctDNA) in cerebrospinal fluid, plays a crucial role in the early diagnosis and precision treatment of gliomas. However, the intrinsically low abundance and rapid clearance of ctDNA pose substantial challenges for conventional analytical techniques, such as droplet digital PCR and ...
Yu Sun +12 more
wiley +1 more source
Glioma-targeting micelles for optical/magnetic resonance dual-mode imaging
, 2015 Qing Zhou,1,* Ketao Mu,2,* Lingyu Jiang,1 Hui Xie,3 Wei Liu,1 Zhengzheng Li,1 Hui Qi,1 Shuyan Liang,1 Huibi Xu,1 Yanhong Zhu,1 Wenzhen Zhu,2 Xiangliang Yang11National Engineering Research Center for Nanomedicine, College of Life Science and Technology ...
Liang S +11 more
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Advanced Science, EarlyView.This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source
Advanced Science, EarlyView.Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan +6 more
wiley +1 more source
Molecular determinants of glioma risk and patient prognosis
, 2012 Gliomas encompass a wide variety of particularly devastating tumors, for which efficient therapies are not available. Their etiology remains mostly undetermined: so far, only exposure to high‐dose therapeutic radiation has been firmly established as a ...
Costa, Bruno Marques +1 more
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