Results 11 to 20 of about 382,034 (365)
Nature Reviews Disease Primers, 2015 Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I–IV, which indicate different degrees of malignancy.
Weller, Michael +10 more
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Nature Cancer, 2021 Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety and efficacy of vaccines against cancer expressing mutant metabolic enzyme IDH1 in patients with high ...
Sameer, Agnihotri +3 more
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Pathogenesis Study of Glioma: From Glioma Stem Cells, Genomic Tags, to Rodent Models [PDF]
, 2023 Despite the past two decades of research progress, glioma still remains the most challenging of all primary central nervous system (CNS) tumors. The complexity of its pathogenesis makes the disease hard to deal with, especially glioblastoma multiforme ...
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Glioma synapses recruit mechanisms of adaptive plasticity
Nature, 2023 The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor^ 1 – 3 (BDNF),
Kathryn R. Taylor +28 more
semanticscholar +1 more source
Glioma targeted therapy: insight into future of molecular approaches
Molecular Cancer, 2022 Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically, gliomas occur among all ages, more often seen in adults, which males are more susceptible than females.
Keyang Yang +13 more
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Frontiers in Immunology, 2017 Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state.
Matteo Massara +12 more
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Genomics, Proteomics & Bioinformatics, 2021 Gliomas are the most common and malignant intracranial tumors in adults. Recent studies have revealed the significance of functional genomics for glioma pathophysiological studies and treatments.
Zheng Zhao +12 more
semanticscholar +1 more source
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
Nature Communications, 2021 Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that ...
Natalia Ochocka +7 more
semanticscholar +1 more source
Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis
Cell, 2021 SUMMARY T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA-seq to chart the gene expression and clonal landscape of tumor-infiltrating T
N. Mathewson +39 more
semanticscholar +1 more source
Molecular Therapy: Nucleic Acids, 2022 High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang +6 more
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