Results 11 to 20 of about 352,265 (309)

Glioma [PDF]

Nature Reviews Disease Primers, 2015
Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I-IV, which indicate different degrees of malignancy.
Weller, Michael, Wick, Wolfgang, Aldape, Ken, Brada, Michael, Berger, Mitchell, Pfister, Stefan M, Nishikawa, Ryo, Rosenthal, Mark, Wen, Patrick Y, Stupp, Roger, Reifenberger, Guido   +10 more
openaire   +4 more sources

SAMD9 Is Relating With M2 Macrophage and Remarkable Malignancy Characters in Low-Grade Glioma

Frontiers in Immunology, 2021
Immunoreactions regulated by TAMs (Tumor-associated macrophages) play a pivotal role in tumorigenesis and metastasis. In recent decades, treatments based on immune regulation have achieved revolutionary breakthroughs in cancer targeted therapies.
Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Kenan Zhang, Zhaoshi Bao, Zhaoshi Bao, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Ying Zhang, Ying Zhang   +14 more
doaj   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BMC Cancer, 2020
Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM.
Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi, Peter Siesjö   +4 more
doaj   +1 more source

Weighted correlation network analysis identifies multiple susceptibility loci for low‐grade glioma

Cancer Medicine, 2023
Background The current molecular classifications cannot completely explain the polarized malignant biological behavior of low‐grade gliomas (LGGs), especially for tumor recurrence.
Xiaodong Niu, Qi Pan, Qianwen Zhang, Xiang Wang, Yanhui Liu, Yu Li, Yuekang Zhang, Yuan Yang, Qing Mao   +8 more
doaj   +1 more source

Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma

Cancer Biology & Medicine, 2021
Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.
Ruichao Chai, Guanzhang Li, Yuqing Liu, Kenan Zhang, Zheng Zhao, Fan Wu, Yuzhou Chang, Bo Pang, Jingjun Li, Yangfang Li, Tao Jiang, Yongzhi Wang   +11 more
doaj   +1 more source

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function [PDF]

, 2016
Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration.
Ammassari-Teule, M, Baroncelli, L, Caleo, M, Costa, M, de Graaf, El, Fabbri, A, Fiorentini, C, Mcdonnell, L, Middei, S, Olimpico, F, Schmidt, G, Vannini, E   +11 more
core   +1 more source

TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas

Cancer Cell International, 2021
Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation is a prognostic marker in adult ...
Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi, Hai Wang   +10 more
doaj   +1 more source

Systematic Analysis of a Pyroptosis-Related Signature to Predict the Prognosis and Immune Microenvironment of Lower-Grade Glioma

Cells, 2022
Current treatments for lower-grade glioma (LGG) do not effectively improve life expectancy rates, and this is a major global health concern. Improving our knowledge of this disease will ultimately help to improve prevention, accurate prognosis, and ...
Yongze He, Yuxiang Cai, Jinsheng Liu, Haixia Ding, Xiang Li, Sufang Tian, Zhiqiang Li   +6 more
doaj   +1 more source

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment [PDF]

, 2016
Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent ...
Catalano, Myriam, Chece, Giuseppina, D'Alessandro, Giuseppina, Di Angelantonio, Silvia, Esposito, Vincenzo, Esposito, Vincenzo, Grimaldi, Alfonso, Limatola, Cristina, Mainiero, Fabrizio, Porzia, Alessandra, Ragozzino, Davide, Salvati, Maurizio, Santoro, Antonio, Wulff, Heike   +13 more
core   +3 more sources