Results 11 to 20 of about 194,510 (268)
Nature Reviews Disease Primers, 2015 Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I–IV, which indicate different degrees of malignancy.
Weller, Michael +10 more
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Nature Cancer, 2021 Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety and efficacy of vaccines against cancer expressing mutant metabolic enzyme IDH1 in patients with high ...
Sameer, Agnihotri +3 more
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ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma
BMC Cancer, 2023 Background Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
Zhen-Yuan Liu +8 more
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Chinese Neurosurgical Journal, 2023 Background PTPRZ1-MET fusion was reported to associate with glioma progression from low-grade to high-grade glioma, which was a target by a MET inhibitor vebreltinib.
Zhaoshi Bao +7 more
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Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma
Frontiers in Oncology, 2020 Methylation of DNA, RNA or protein is a reversible modification. The proteins and genes that regulate this modification can be a candidate target for tumor therapy. However, the characteristics of methyltransferase related genes in glioma remain obscure.
Ying Zhang +11 more
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EBioMedicine, 2023 Summary: Background: Human oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion.
Fan Wu +9 more
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Discover Oncology, 2023 Objective TERT is the most frequently mutated gene in adult glioblastomas (GBMs) defined by the 2021 World Health Organization classification system. The present study aims to explore differences in clinical characteristics and immune microenvironment ...
Feng Tang +6 more
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Frontiers in Immunology, 2017 Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state.
Matteo Massara +12 more
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Angiocentric glioma: the infiltrative glioma with ependymal differentiation [PDF]
Turkish Journal of Pathology, 2013 Angiocentric glioma is an epileptogenic, infiltrative, low grade glial tumor, with ependymal and astrocytic differentiation, most commonly seen in young adults and the pediatric age group. Herein we report a case of 21-year-old male patient who presented with fever and pharmaco-resistant seizures.
Ersen, Ayca +5 more
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Molecular Therapy: Nucleic Acids, 2022 High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang +6 more
doaj +1 more source