Results 11 to 20 of about 202,951 (216)
PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma. [PDF]
Ann Clin Transl NeurolABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Chen Y +7 more
europepmc +2 more sources
BMC Cancer, 2020 Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM.
Julio Enríquez Pérez +4 more
doaj +1 more source
Cells, 2022 Current treatments for lower-grade glioma (LGG) do not effectively improve life expectancy rates, and this is a major global health concern. Improving our knowledge of this disease will ultimately help to improve prevention, accurate prognosis, and ...
Yongze He +6 more
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Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma
Cancer Biology & Medicine, 2021 Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.
Ruichao Chai +11 more
doaj +1 more source
TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas
Cancer Cell International, 2021 Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation is a prognostic marker in adult ...
Sidi Xie +10 more
doaj +1 more source
Frontiers in Oncology, 2022 Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyang Guo +13 more
doaj +1 more source
Gene Expression Profiling Stratifies IDH-Wildtype Glioblastoma With Distinct Prognoses
Frontiers in Oncology, 2019 Objectives: In the present study, we aimed to determine the candidate genes that may function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM), which are heterogeneous with respect to clinical ...
Yu-Qing Liu +13 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 BackgroundAs a critical organelle for protein and lipid synthesis, the dysfunction of endoplasmic reticulum has a significant impact on multiple biological processes of cells.
Ruoyu Huang +17 more
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Scientific Reports, 2022 Glioblastoma has remained the deadliest primary brain tumor while its current therapy offers only modest survival prolongation. Immunotherapy has failed to record notable benefits in routine glioblastoma treatment. Conventionally, immunotherapy relies on
Jan Kopecky +5 more
doaj +1 more source
Cancer Cell International, 2019 Background The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the pathogenesis of tumors. This study
Shuai Wu +5 more
doaj +1 more source