Results 21 to 30 of about 382,034 (365)

Diffuse Glioma Heterogeneity and Its Therapeutic Implications.

Cancer Discovery, 2021
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies.
James G Nicholson, H. Fine
semanticscholar   +1 more source

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing

Frontiers in Neurology, 2023
ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang, Chuan-bao Zhang, Zhi-liang Wang, Zhi-liang Wang, Han-jie Liu, Han-jie Liu, Zheng Wang, Zheng Wang, Wang Jia, Wang Jia   +9 more
doaj   +1 more source

Extracranial metastasis of anaplastic oligoastrocytoma

Cancer Biology & Medicine, 2018
Extracranial metastasis (ECM) of glioma is a rare condition that occurs in the internal nervous axis. A 23-year-old woman presented with anaplastic oligoastrocytoma (WHO III) in a left temporal tumor.
Zhuang Kang, Shoubo Yang, Hongmei Zhang, Quan Zhou, Jianxin Chen, Yan Li, Xun Kang, Shan Li, Wenbin Li   +8 more
doaj   +1 more source

Weighted correlation network analysis identifies multiple susceptibility loci for low‐grade glioma

Cancer Medicine, 2023
Background The current molecular classifications cannot completely explain the polarized malignant biological behavior of low‐grade gliomas (LGGs), especially for tumor recurrence.
Xiaodong Niu, Qi Pan, Qianwen Zhang, Xiang Wang, Yanhui Liu, Yu Li, Yuekang Zhang, Yuan Yang, Qing Mao   +8 more
doaj   +1 more source

SAMD9 Is Relating With M2 Macrophage and Remarkable Malignancy Characters in Low-Grade Glioma

Frontiers in Immunology, 2021
Immunoreactions regulated by TAMs (Tumor-associated macrophages) play a pivotal role in tumorigenesis and metastasis. In recent decades, treatments based on immune regulation have achieved revolutionary breakthroughs in cancer targeted therapies.
Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Kenan Zhang, Zhaoshi Bao, Zhaoshi Bao, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Ying Zhang, Ying Zhang   +14 more
doaj   +1 more source

Contribution of 3q26-29 gene cluster to glioma invasion [PDF]

, 2015
Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core   +1 more source

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BMC Cancer, 2020
Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM.
Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi, Peter Siesjö   +4 more
doaj   +1 more source

Systematic Analysis of a Pyroptosis-Related Signature to Predict the Prognosis and Immune Microenvironment of Lower-Grade Glioma

Cells, 2022
Current treatments for lower-grade glioma (LGG) do not effectively improve life expectancy rates, and this is a major global health concern. Improving our knowledge of this disease will ultimately help to improve prevention, accurate prognosis, and ...
Yongze He, Yuxiang Cai, Jinsheng Liu, Haixia Ding, Xiang Li, Sufang Tian, Zhiqiang Li   +6 more
doaj   +1 more source

Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features

Scientific Data, 2017
Gliomas belong to a group of central nervous system tumors, and consist of various sub-regions. Gold standard labeling of these sub-regions in radiographic imaging is essential for both clinical and computational studies, including radiomic and ...
S. Bakas, H. Akbari, Aristeidis Sotiras, M. Bilello, Martin Rozycki, J. Kirby, J. Freymann, K. Farahani, C. Davatzikos   +8 more
semanticscholar   +1 more source

Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma

Cancer Biology & Medicine, 2021
Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.
Ruichao Chai, Guanzhang Li, Yuqing Liu, Kenan Zhang, Zheng Zhao, Fan Wu, Yuzhou Chang, Bo Pang, Jingjun Li, Yangfang Li, Tao Jiang, Yongzhi Wang   +11 more
doaj   +1 more source