Results 201 to 210 of about 194,510 (268)

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

Reprogramming the immune suppressive tumor microenvironment in glioma enhances the efficacy of immune-mediated gene therapy. [PDF]

Mol Ther Oncol
McClellan BL, Peña Agudelo JA, Mujeeb AA, Dabaja AA, Zhu Z, Raghuram S, Varela ML, Tronrud C, Banerjee K, Wei A, Calatroni C, Zhang LH, Romero LC, Oh P, Alghamri MS, Robbins A, Perricone M, Wang Y, Shay B, Sajjakulnukit P, Lyssiotis CA, Welch JD, Schwendeman A, Lowenstein PR, Castro MG.   +24 more
europepmc   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Central Nervous System Tumors in Xeroderma Pigmentosum: Five Cases and Review of the Literature

Movement Disorders, EarlyView.
Abstract Background Xeroderma pigmentosum (XP) is a rare autosomal recessive DNA‐repair disorder characterized by extreme ultraviolet radiation (UVR) sensitivity, markedly increased cutaneous malignancy risk, and progressive neurological disease in approximately one‐third of patients.
Farrah S. Bakr, Huseyin Arisoy, Alan R. Lehmann, Paola Giunti, Hiva Fassihi   +4 more
wiley   +1 more source

MAGMAS Inhibition Enhances Temozolomide Efficacy in Chemotherapy-Resistant Glioblastoma Models. [PDF]

Cancer Res Commun
Lepe JJ, Tran JD, Lomeli N, Dang VP, Nguyen VC, Chokkalingam P, Das S, Das BC, Bota DA.   +8 more
europepmc   +1 more source

Single-Cell and Spatial Transcriptomics Reveals Selenoproteins Shape Immunosuppressive Microenvironment and Therapeutic Outcomes in Glioma. [PDF]

Cancers (Basel)
Zhang X, Zhang N, Zhong Y, Ou S, Wu G, Ouyang T, He K.   +6 more
europepmc   +1 more source

Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA. [PDF]

Front Immunol
Wang K, Xu F, Zhu L, Wang J, Li H, Cao X, Wang X, Zong D, Liu Y, Shao J.   +9 more
europepmc   +1 more source

Glioma-derived extracellular vesicles as drivers of immunotherapeutic resistance: mechanisms of immune reprogramming and metabolic intervention. [PDF]

Front Immunol
Wang J, Peng B, Li T, Wang T.
europepmc   +1 more source

SIRT5-RNF126 coordinated regulation of METTL17 stability controls mitochondrial function and glioma progression. [PDF]

Cell Biosci
He C, Zhang Z, Wu X, Lin C, Jin J, Ni Y, Qian Y, Wang Y.   +7 more
europepmc   +1 more source