Results 201 to 210 of about 382,034 (365)

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Neurotransmitter-Mediated Signaling in Glioblastoma and Glial Tumors: Biology and Therapeutic Opportunities. [PDF]

Oncol Res
Tralongo P, Ballato M, Zuccalà V, Fiorentino V, Giordano W, Casili G, Bellinghieri F, Caruso G, Angileri FF, Fadda G, Martini M, Caffo M.   +11 more
europepmc   +1 more source

Decrease in Ca2+-Activated K+ Conductance in Differentiated C6-Glioma Cells

, 2009
Ca2+-activated K+ channels were studied in C6-glioma cells in an attempt to correlate changes in expression with cell proliferation and differentiation. In this study, we treated C6-glioma cells with thapsigargin for 48 h. Cell proliferation was markedly
KUO, TSUN-CHENG;LIN-SHIAU, SHOEI-YN, 郭俊成;蕭水銀   +1 more
core  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Characterizing malignant prognostic signatures in primary glioma based on single-cell and bulk transcriptome sequencing. [PDF]

PLoS One
Gong Y, Guo H, Ding H, Hu X, Ding Z, Ma M, Chen J.   +6 more
europepmc   +1 more source

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.

Cancer Cell, 2010
H. Noushmehr, D. Weisenberger, K. Diefes, H. Phillips, Kanan D. Pujara, B. Berman, F. Pan, C. Pelloski, E. Sulman, K. Bhat, R. Verhaak, K. Hoadley, D. Hayes, C. Perou, Heather K. Schmidt, L. Ding, R. Wilson, D. J. Van Den Berg, Hui Shen, H. Bengtsson, P. Neuvial, L. Cope, J. Buckley, J. Herman, S. Baylin, P. Laird, K. Aldape   +26 more
semanticscholar   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Urine and cerebrospinal fluid biomarkers for early glioma detection: a systematic review. [PDF]

Diagn Progn Res
Paterson C, Yu J, Davies P, Read J, Palmer JC, Dawson S, Higgins JP, Kurian KM.   +7 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Caregiver burden, quality of life, and psychosocial outcomes among informal caregivers of patients with glioma: A systematic review and meta-analysis. [PDF]

Asia Pac J Oncol Nurs
Wei H, Zhang S, Tao S, Li J, Liu X.
europepmc   +1 more source