Results 21 to 30 of about 540,674 (406)
CNS Oncology, 2015 The treatment of glial brain tumors begins with surgery, and standard adjuvant treatment at the end of the past millennium for high-grade glioma and high-risk low-grade glioma was radiotherapy and chemotherapy was given at recurrence. However, over the past 10 years much has changed regarding the role of chemotherapy in gliomas and it is now clear that
Jacoline E C Bromberg +2 more
openaire +4 more sources
Extracranial metastasis of anaplastic oligoastrocytoma
Cancer Biology & Medicine, 2018 Extracranial metastasis (ECM) of glioma is a rare condition that occurs in the internal nervous axis. A 23-year-old woman presented with anaplastic oligoastrocytoma (WHO III) in a left temporal tumor.
Zhuang Kang +8 more
doaj +1 more source
Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma
Cancer Biology & Medicine, 2021 Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.
Ruichao Chai +11 more
doaj +1 more source
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]
, 2016 Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M +11 more
core +2 more sources
bioRxiv, 2020 Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids in the understanding of the pathophysiology and therapy of glioma.
Zheng Zhao +12 more
semanticscholar +1 more source
BMC Cancer, 2020 Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM.
Julio Enríquez Pérez +4 more
doaj +1 more source
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
British Journal of Cancer, 2020 Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis.
Sue Han +7 more
semanticscholar +1 more source
TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas
Cancer Cell International, 2021 Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation is a prognostic marker in adult ...
Sidi Xie +10 more
doaj +1 more source
Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function [PDF]
, 2016 Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration.
Ammassari-Teule, M +11 more
core +1 more source
Scientific Data, 2017 Gliomas belong to a group of central nervous system tumors, and consist of various sub-regions. Gold standard labeling of these sub-regions in radiographic imaging is essential for both clinical and computational studies, including radiomic and ...
S. Bakas +8 more
semanticscholar +1 more source