Results 21 to 30 of about 248,997 (274)

An online survival predictor in glioma patients using machine learning based on WHO CNS5 data

Frontiers in Neurology, 2023
BackgroundThe World Health Organization (WHO) CNS5 classification system highlights the significance of molecular biomarkers in providing meaningful prognostic and therapeutic information for gliomas.
Liguo Ye, Lingui Gu, Zhiyao Zheng, Zhiyao Zheng, Zhiyao Zheng, Xin Zhang, Hao Xing, Xiaopeng Guo, Xiaopeng Guo, Wenlin Chen, Yaning Wang, Yuekun Wang, Tingyu Liang, Hai Wang, Yilin Li, Yilin Li, Shanmu Jin, Shanmu Jin, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Qianshu Liu, Qianshu Liu, Congcong Deng, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +30 more
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Mathematical Model of the Impact of Chemotherapy and Anti-Angiogenic Therapy on Drug Resistance in Glioma Growth [PDF]

arXiv, 2023
This research presents a mathematical model of glioma growth dynamics with drug resistance, capturing interactions among five cell populations: glial cells, sensitive glioma cells, resistant glioma cells, endothelial cells, and neuron cells, along with two therapy agent populations: chemotherapy and anti-angiogenic therapy.
arxiv  

NK Cell-Based Immunotherapy and Therapeutic Perspective in Gliomas

Frontiers in Oncology, 2021
Glioma is the most common malignant primary brain tumor diagnosed in adults. Current therapies are unable to improve its clinical prognosis, imposing the need for innovative therapeutic approaches. The main reason for the poor prognosis is the great cell
Changqing Pan, You Zhai, Guanzhang Li, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang   +10 more
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Inferring diagnostic and prognostic gene expression signatures across WHO glioma classifications: A network-based approach [PDF]

arXiv, 2023
Tumor heterogeneity is a challenge to designing effective and targeted therapies. Glioma-type identification depends on specific molecular and histological features, which are defined by the official WHO classification CNS. These guidelines are constantly updated to support the diagnosis process, which affects all the successive clinical decisions.
arxiv  

Immunological profiles of human oligodendrogliomas define two distinct molecular subtypesResearch in context

EBioMedicine, 2023
Summary: Background: Human oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion.
Fan Wu, Yi-Yun Yin, Wen-Hua Fan, You Zhai, Ming-Chen Yu, Di Wang, Chang-Qing Pan, Zheng Zhao, Guan-Zhang Li, Wei Zhang   +9 more
doaj  

Germline predisposition to glial neoplasms in children and young adults: A narrative review

Glioma, 2021
Gliomas are the most common malignancies of the central nervous system (CNS). A significant proportion of both low- and high-grade gliomas in children, adolescents, and young adults have specific genetic events which can be traced to the germline ...
Anirban Das, Cynthia Hawkins, Uri Tabori   +2 more
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A Computational Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence across the Lifespan in the Human Population [PDF]

Bauer, Roman, Marcus Kaiser, and Elizabeth Stoll. "A Computational Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence across the Lifespan in the Human Population." PloS one 9.11 (2014): e111219, 2015
Glioma is the most common form of primary brain tumor. Demographically, the risk of occurrence increases until old age. Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan. Previous mathematical models explaining glioma incidence are framed in a rather abstract way, and do not directly relate
arxiv   +1 more source

Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression

Molecular Therapy: Nucleic Acids, 2022
High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang, Chao Yang, Feng-Ping Li, Dong-Hu Yu, Zhi-Yong Pan, Ze-Fen Wang, Zhi-Qiang Li   +6 more
doaj  

Cross-modality Attention Adapter: A Glioma Segmentation Fine-tuning Method for SAM Using Multimodal Brain MR Images [PDF]

arXiv, 2023
According to the 2021 World Health Organization (WHO) Classification scheme for gliomas, glioma segmentation is a very important basis for diagnosis and genotype prediction. In general, 3D multimodal brain MRI is an effective diagnostic tool. In the past decade, there has been an increase in the use of machine learning, particularly deep learning, for ...
arxiv  

Novel insight into histological and molecular astrocytoma, IDH‐mutant, Grade 4 by the updated WHO classification of central nervous system tumors

Cancer Medicine, 2023
Background The latest fifth edition of the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH‐mutant, Grade 4.
Wenlin Chen, Siying Guo, Yaning Wang, Yixin Shi, Xiaopeng Guo, Delin Liu, Yilin Li, Yuekun Wang, Hao Xing, Yu Xia, Junlin Li, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma   +21 more
doaj   +1 more source