Results 41 to 50 of about 540,674 (406)

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]

, 2020
Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching, Chang, Hao-Fang, Chen, Bing-Mao, Chen, Shih-Han, Chen, Thomas C, Collins, Sara, Kasahara, Noriyuki, Lin, Sheng-Che, Lu, Yin-Che, Sun, Jui-Ming, Tai, Chien-Kuo, Wang, Hsin-Ell, Wang, Weijun, Wu, Shu-Fen   +13 more
core   +2 more sources

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

Autophagy, 2021
Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against glioma; however, the molecular target and mechanism
Tengfei Huang, Tianqi Xu, Yangfan Wang, Yan Zhou, Dandan Yu, Zhiyuan Wang, Linfang He, Zhangpeng Chen, Yaliang Zhang, Don Davidson, Yuyuan Dai, C. Hang, Xiangyu Liu, C.-Q. Yan   +13 more
semanticscholar   +1 more source

On the origin of glioma [PDF]

Upsala Journal of Medical Sciences, 2012
Glioma is the most frequent primary brain tumor of adults that has a presumably glial origin. Although our knowledge regarding molecular mechanisms and signaling pathways involved in gliomagenesis has increased immensely during the past decade, high-grade glioma remains a lethal disease with dismal prognosis.
Yiwen Jiang, Lene Uhrbom
openaire   +3 more sources

Gene Expression Profiling Stratifies IDH-Wildtype Glioblastoma With Distinct Prognoses

Frontiers in Oncology, 2019
Objectives: In the present study, we aimed to determine the candidate genes that may function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM), which are heterogeneous with respect to clinical ...
Yu-Qing Liu, Yu-Qing Liu, Fan Wu, Fan Wu, Jing-Jun Li, Jing-Jun Li, Yang-Fang Li, Yang-Fang Li, Xing Liu, Xing Liu, Zheng Wang, Zheng Wang, Rui-Chao Chai, Rui-Chao Chai   +13 more
doaj   +1 more source

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
B. Martin, Bourdon, Bullard, Bullard, Carrel, Coakham, Coakham, D. Stavrou, De Muralt, E. Keiditsch, Epenetos, F. Schmidberger, I. Funke, Jonak, K. Bise, Kearney, Kemshead, Krajewski, Köhler, Lanier, Posner, R. Kurrle, Roholl, Schnegg, Seeger, Sikora, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Stavrou, Taub, U. Stocker, W. Eisenmenger, Wikstrand   +36 more
core   +1 more source

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Journal of Hematology & Oncology, 2021
Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding, Liangliang Wang, Xue-dong Zhang, Junlong Xu, Pei-feng Li, H. Liang, Xianbin Zhang, Li Xie, Zihan Zhou, Jia Yang, R. Weichselbaum, Jinming Yu, M. Hu   +12 more
semanticscholar   +1 more source

Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway

Cancer Cell International, 2019
Background The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the pathogenesis of tumors. This study
Shuai Wu, Chen Luo, Fengjiao Li, N. U. Farrukh Hameed, Qiuyan Jin, Jie Zhang   +5 more
doaj   +1 more source

An online survival predictor in glioma patients using machine learning based on WHO CNS5 data

Frontiers in Neurology, 2023
BackgroundThe World Health Organization (WHO) CNS5 classification system highlights the significance of molecular biomarkers in providing meaningful prognostic and therapeutic information for gliomas.
Liguo Ye, Lingui Gu, Zhiyao Zheng, Zhiyao Zheng, Zhiyao Zheng, Xin Zhang, Hao Xing, Xiaopeng Guo, Xiaopeng Guo, Wenlin Chen, Yaning Wang, Yuekun Wang, Tingyu Liang, Hai Wang, Yilin Li, Yilin Li, Shanmu Jin, Shanmu Jin, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Qianshu Liu, Qianshu Liu, Congcong Deng, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +30 more
doaj   +1 more source

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

, 2008
Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato, A Bagnato, AV Budanov, D Salani, ER Levin, F Spinella, G Egidy, G Pan, H Peeters, H Walczak, HT Adler, J Eberle, J Nelson, JB Nelson, JD Stiles, Jennifer P Montgomery, JP Sheridan, JR Wu-Wong, K Ishikawa, K Kikuchi, K Takahashi, L Rosano, L Rosano, M Matsumoto, M Nagane, M Sone, M Takekawa, MC Hollander, N Kitagawa, Paul H Patterson, Q Zhan, Q Zhan, R Lahav, R Lahav, S He, S Jin, S Jin, S Velasco-Miguel, SP Harland, U Pagotto, V Naidoo, XW Wang, Y Berger   +42 more
core   +3 more sources

Glioma: molecular signature and crossroads with tumor microenvironment

Cancer Metastasis Review, 2021
In patients with glioblastoma, the average survival time with current treatments is short, mainly due to recurrences and resistance to therapy. This insufficient treatment success is, in large parts, due to the tremendous molecular heterogeneity of ...
L. Barthel, M. Hadamitzky, P. Dammann, M. Schedlowski, U. Sure, B. K. Thakur, S. Hetze   +6 more
semanticscholar   +1 more source