Results 51 to 60 of about 540,674 (406)

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]

, 2017
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C, BERNARDINI, Giovanni, CARDINALI, CLAUDIO, MORELLI, MARIA BEATRICE, Nabissi, M, SANTONI, Angela, Santoni, G., Santoni, M   +7 more
core   +1 more source

NK Cell-Based Immunotherapy and Therapeutic Perspective in Gliomas

Frontiers in Oncology, 2021
Glioma is the most common malignant primary brain tumor diagnosed in adults. Current therapies are unable to improve its clinical prognosis, imposing the need for innovative therapeutic approaches. The main reason for the poor prognosis is the great cell
Changqing Pan, You Zhai, Guanzhang Li, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang   +10 more
doaj   +1 more source

Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment [PDF]

, 2015
Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: Fundação Araucária, EPSRC-EP/I032606/1 and CNPq, CAPES and Science Without Borders Program Process nos. 17656125, 99999.010583/2013-00
Baptista, Murilo Da Silva, Baptista, Murilo S., Batista, Antonio M., Borges, Fernando S., Iarosz, Kelly C., Lopes, Sergio R., Siqueira, Regiane A. N., Viana, Ricardo L.   +7 more
core   +1 more source

Angiogenesis in gliomas.

Folia Histochemica et Cytobiologica, 2008
Brain gliomas are characterized by invasive growth and neovascularisation potential. Angiogenesis plays a major role in the progression of gliomas and its determination has a great prognostic value. The aim of the study was to assess the vascularisation of chosen brain gliomas and to estimate how it is correlated with tumour histological type ...
Janusz Dzięcioł, Dorota Lemancewicz, Katarzyna Guzińska-Ustymowicz, Elzbieta Czykier, Lech Zimnoch, A Lebelt   +5 more
openaire   +5 more sources

LONGITUDINAL MOLECULAR TRAJECTORIES OF DIFFUSE GLIOMA IN ADULTS

Nature, 2019
The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma.
F. Barthel, K. Johnson, F. Varn, A. Moskalik, Georgette Tanner, E. Kocakavuk, K. Anderson, O. Abiola, K. Aldape, Kristin D. Alfaro, D. Alpár, S. Amin, D. Ashley, P. Bandopadhayay, J. Barnholtz-Sloan, R. Beroukhim, C. Bock, P. Brastianos, D. Brat, A. Brodbelt, A. Bruns, K. Bulsara, A. Chakrabarty, A. Chakravarti, Jeffrey H. Chuang, E. Claus, E. Cochran, J. Connelly, J. Costello, G. Finocchiaro, M. Fletcher, P. French, H. Gan, M. Gilbert, P. Gould, M. Grimmer, A. Iavarone, Azzam Ismail, M. Jenkinson, M. Khasraw, Hoon Kim, M. Kouwenhoven, P. LaViolette, Meihong Li, P. Lichter, K. Ligon, A. Lowman, T. Malta, T. Mazor, K. McDonald, A. Molinaro, D. Nam, Naema Nayyar, H. Ng, C. Ngan, S. Niclou, J. M. Niers, H. Noushmehr, J. Noorbakhsh, D. Ormond, Chul-Kee Park, L. Poisson, R. Rabadán, B. Radlwimmer, G. Rao, G. Reifenberger, J. Sa, M. Schuster, Brian L. Shaw, S. Short, P. Smitt, A. Sloan, M. Smits, Hiromichi Suzuki, G. Tabatabai, Erwin G. Van Meir, C. Watts, M. Weller, P. Wesseling, B. Westerman, G. Widhalm, A. Woehrer, W. Yung, G. Zadeh, J. Huse, J. Groot, Lucy F. Stead, R. Verhaak   +87 more
semanticscholar   +1 more source

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi, Angelo Sarra, Barbara Ruzicka, Carmela Serpe, Cristina Limatola, Cristina Limatola, Francesca Guerrieri, Giancarlo Ruocco, Giuseppe Familiari, Giuseppe Rubens Pascucci, Giuseppina Chece, Michela Relucenti, Myriam Catalano, Myriam Catalano, Valentina Nigro   +14 more
core   +5 more sources

Pediatric low-grade glioma in the era of molecular diagnostics

Acta Neuropathologica Communications, 2020
Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their
S. Ryall, U. Tabori, C. Hawkins
semanticscholar   +1 more source

Immune Checkpoint Inhibitors in Human Glioma Microenvironment

Frontiers in Immunology, 2021
Gliomas are the most common primary brain tumors in adults. Despite the fact that they are relatively rare, they cause significant morbidity and mortality. High-grade gliomas or glioblastomas are rapidly progressing tumors with a very poor prognosis. The
Amina Ghouzlani, S. Kandoussi, M. Tall, Konala Priyanka Reddy, S. Rafii, Abdallah Badou   +5 more
semanticscholar   +1 more source

Germline predisposition to glial neoplasms in children and young adults: A narrative review

Glioma, 2021
Gliomas are the most common malignancies of the central nervous system (CNS). A significant proportion of both low- and high-grade gliomas in children, adolescents, and young adults have specific genetic events which can be traced to the germline ...
Anirban Das, Cynthia Hawkins, Uri Tabori   +2 more
doaj   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source