Results 81 to 90 of about 424,107 (362)
Molecular and clinical characterization of TIM-3 in glioma through 1,024 samples
OncoImmunology, 2017 Background: Researches on immunotherapy of glioma has been increasing exponentially in recent years. However, autoimmune-like side effects of current immune checkpoint blockade hindered the clinical application of immunotherapy in glioma.
Guanzhang Li +15 more
doaj +1 more source
Medical Hypotheses, 2012 Glial neoplasms account for nearly 50% of all adult primary brain tumors. They originate from glial cells in the brain and/or spinal cord and include low-grade diffuse astrocytomas, anaplastic-astrocytomas, and glioblastomas. Of all brain tumors, glioblastoma multiforme (GBM) is the most aggressive and is characterized by rapid glial cell growth ...
Alberto E. Musto +4 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
BMC CancerBackground Gliomas are the deadliest malignant tumors of the adult central nervous system. We previously discovered that beta2-microglobulin (B2M) is abnormally upregulated in glioma tissues and that it exerts a range of oncogenic effects.
Zhen-Yuan Liu +6 more
doaj +1 more source
Advancement of clinical therapeutic research on glioma: A narrative review
Glioma, 2020 As theories evolve, the mechanism of glioma origination remains poorly understood. Understanding this mechanism promotes the clinical research on glioma therapeutic strategy and then improves the prognosis of patients with glioma.
Fengping Li +4 more
doaj +1 more source
The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. [PDF]
, 2017 EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown.
Atkin, Naomi +16 more
core +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Prolactin and its receptor as therapeutic targets in glioblastoma multiforme [PDF]
, 2019 Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis.
Abt, Araceli +13 more
core +1 more source
Synthetic Antiferromagnetic Designer Nanodisks for High‐Performance Magnetic Separation
Advanced Healthcare Materials, EarlyView.Micromagnetic‐modeling‐based design and scalable fabrication of synthetic antiferromagnet (SAF) magnetic disk particles (MDPs) using sputter deposition enable high‐performance magnetic separation. The SAF MDPs achieve high colloidal stability and magnetic responsiveness and enable efficient magnetic separation, outperforming conventional particles ...
Subas Scheibler +14 more
wiley +1 more source
Glioma, 2020 Recent advances in genetic and molecular characterization of telomere maintenance mechanisms (TMMs) highlighted their strong relationship with cancer pathogenesis; neoplastic cells rely on two mechanisms to maintain telomere length and escape from ...
Simone Minasi +5 more
doaj +1 more source