Results 151 to 160 of about 264,589 (263)

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Identification of exosome miRNAs regulated by SPHK2 in human glioma cells. [PDF]

Front Oncol
Liu J, Zhao H, Liu X, Guan X, Guo Q, Xu Y, Qiu J.   +6 more
europepmc   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie International Edition, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

NEIL1 suppresses ROS accumulation to promote temozolomide resistance and malignant progression in glioma cells. [PDF]

Transl Oncol
Li S, Fang C, Yuan Q, Chen X.
europepmc   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sérgio Duvoisin Junior, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
wiley   +1 more source

SETD5 in glioma cells conferred TRAIL resistance induction. [PDF]

Sci Rep
Taneja L, Bhardwaj S, Yadav AK.
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

PAX6 Downregulation Triggers HIF-1α-Mediated Ferroptosis in Glioma Cells. [PDF]

Biomolecules
Luo Q, Fu L, Zhang J, Zhang S, Wu L, Zhu Q, Huang B.   +6 more
europepmc   +1 more source