Results 191 to 200 of about 264,589 (263)

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, EarlyView.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Proteomic Analysis Uncovers Enhanced Inflammatory Phenotype and Distinct Metabolic Changes in IDH1 Mutant Glioma Cells. [PDF]

Int J Mol Sci
Ravn Berg S, Brambilla A, Hagen L, Sharma A, Vågbø CB, Liabakk NB, Kissova M, Arano Barenys M, Bjørås M, Torp SH, Slupphaug G.   +10 more
europepmc   +1 more source

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

Small Extracellular Vesicles From Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response. [PDF]

J Extracell Vesicles
Oza VD, Flores KA, Chernyavskaya Y, Al-Hamaly MA, Smith CB, Bruntz RC, Blackburn JS.   +6 more
europepmc   +1 more source

Phase‐Change Assembling Nanostructures Synergistically Potentiate Tumor Radiosensitivity by Reducing the Stemness of Cancer Stem‐Like Cells

Exploration, EarlyView.
A eutectic phase‐change mixture of natural fatty acids was introduced to serve as a gating material for the near‐infrared‐triggered precise release of oxygen and nitroimidazole radiosensitizer in tumors. The stemness of cancer stem‐like cells was shown to be significantly reduced through the delivery of oxygen to deep tumors.
Yuanfang Chen, Xueyin Hu, Ze Hu, Yuwei Yang, Changfen Bi, Guangyou Shi, Lumeng Zhang, Wenqing Xu, Shuqin Li, Luntao Liu   +9 more
wiley   +1 more source

Regulatory mechanisms of O6-methylguanine methyltransferase expression in glioma cells. [PDF]

Sci Prog
Fang C, Zhang G, Ye S, Tian S, Li H, Zuo F, Wan J, Cai H.   +7 more
europepmc   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

PDGF-D Promotes Epithelial-Mesenchymal Transition of Glioma Cells Through the NF-κB/NOTCH1 Pathway. [PDF]

Cancer Med
Li Y, Zhao Y, Shi M, Ma X, Jia M, Shen Z, Liu X, Li Y, Zhao L.   +8 more
europepmc   +1 more source

Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it ...
Yuki Hosokawa, Shoko Miyoshi, Yuji Hayashi, Yuki Irifune, Eriko Sato, Sohei Mitani, Mohammed Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato   +9 more
wiley   +1 more source

Curcumin-Induced Apoptotic Cell Death in Human Glioma Cells Is Enhanced by Clusterin Deficiency. [PDF]

Pharmaceutics
Sultana P, Novotny J.
europepmc   +1 more source